Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Demannose. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | FPR2 | P25090 | 2/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.32 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Demannose SCHEMBL4650609 | 0.95 | PDE4A (0.40) | PDE4ALMNAUSP2SLCO1B1L3MBTL1 | |
| Demannose SCHEMBL6346866 | 0.93 | PDE4A (0.38) | PDE4ALMNAUSP2SLCO1B1L3MBTL1 | |
| Demannose SCHEMBL4651152 | 0.92 | PDE4A (0.42) | PDE4ALMNAUSP2SLCO1B1L3MBTL1 | |
| Demannose SCHEMBL31490918 | 0.90 | PDE4A (0.47) | PDE4ALMNAUSP2SLCO1B1L3MBTL1 | |
| Demannose SCHEMBL21570729 | 0.90 | PDE4A (0.47) | PDE4ALMNAUSP2SLCO1B1L3MBTL1 | |
| Demannose SCHEMBL4444321 | 0.90 | PDE4A (0.47) | PDE4ALMNAUSP2SLCO1B1L3MBTL1 | |
| Demannose SCHEMBL11509811 | 0.90 | PDE4A (0.47) | PDE4ALMNAUSP2SLCO1B1L3MBTL1 | |
| Demannose SCHEMBL28531529 | 0.89 | FFAR3 (0.43) | PDE4ALMNAUSP2SLCO1B1L3MBTL1 | |
| Demannose SCHEMBL7869242 | 0.89 | PDE4A (0.40) | PDE4ALMNAUSP2SLCO1B1L3MBTL1 | |
| Demannose SCHEMBL5586151 | 0.87 | FFAR3 (0.45) | PDE4ALMNAUSP2SLCO1B1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007035589-A1 | MINIMAL GROWTH MEDIUM FOR ACTINOBACILLUS SUCCINOGENES | MICHIGAN STATE UNIVERSITY (US) | 2007-03-29 | — | — | WO | disclosed |