Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 20/20 | 0.70 |
| ▸ | PIK3CA | P42336 | 9/20 | 0.70 |
| ▸ | RPTOR | Q8N122 | 8/20 | 0.70 |
| ▸ | MLST8 | Q9BVC4 | 8/20 | 0.70 |
| ▸ | RICTOR | Q6R327 | 3/20 | 0.70 |
| ▸ | MAPKAP1 | Q9BPZ7 | 3/20 | 0.70 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL531241 | 0.83 | MTOR (0.69) | MTORPIK3CARPTORMLST8RICTOR | |
| SCHEMBL138388 | 0.82 | MTOR (1.00) | MTORPIK3CARPTORMLST8RICTOR | |
| SCHEMBL136223 | 0.75 | MTOR (1.00) | MTORPIK3CARPTORMLST8RICTOR | |
| SCHEMBL29522556 | 0.75 | MTOR (1.00) | MTORPIK3CARPTORMLST8RICTOR | |
| SCHEMBL137103 | 0.75 | MTOR (0.84) | MTORPIK3CARPTORMLST8RICTOR | |
| SCHEMBL29522077 | 0.75 | MTOR (0.84) | MTORPIK3CARPTORMLST8RICTOR | |
| SCHEMBL530692 | 0.75 | MTOR (0.58) | MTORPIK3CARPTORMLST8RICTOR | |
| SCHEMBL530988 | 0.71 | MTOR (0.71) | MTORPIK3CARPTORMLST8RICTOR | |
| SCHEMBL22396620 | 0.71 | MTOR (1.00) | MTORPIK3CARPTORMLST8RICTOR | |
| SCHEMBL15644344 | 0.67 | MTOR (0.47) | MTORPIK3CARPTORMLST8RICTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2598885-A1 | BIOMARKER ASSAYS FOR DETECTING OR MEASURING INHIBITION OF TOR KINASE ACTIVITY | Signal Pharmaceuticals, LLC (US) | 2013-06-05 | — | — | EP | claimed |
| WO-2012016113-A1 | BIOMARKER ASSAYS FOR DETECTING OR MEASURING INHIBITION OF TOR KINASE ACTIVITY | SIGNAL PHARMACEUTICALS, LLC (US) | 2012-02-02 | — | — | WO | claimed |