Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 20/20 | 0.58 |
| ▸ | RPTOR | Q8N122 | 7/20 | 0.56 |
| ▸ | MLST8 | Q9BVC4 | 7/20 | 0.56 |
| ▸ | RICTOR | Q6R327 | 3/20 | 0.56 |
| ▸ | MAPKAP1 | Q9BPZ7 | 3/20 | 0.56 |
| ▸ | CSF1R | P07333 | 1/20 | 0.56 |
| ▸ | PIK3CA | P42336 | 9/20 | 0.45 |
| ▸ | GSK3A | P49840 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL531241 | 0.92 | MTOR (0.69) | MTORRPTORMLST8RICTORMAPKAP1 | |
| SCHEMBL530988 | 0.89 | MTOR (0.71) | MTORRPTORMLST8RICTORMAPKAP1 | |
| SCHEMBL138690 | 0.81 | MTOR (0.85) | MTORRPTORMLST8RICTORMAPKAP1 | |
| SCHEMBL530735 | 0.80 | MTOR (0.68) | MTORRPTORMLST8RICTORMAPKAP1 | |
| SCHEMBL530574 | 0.75 | MTOR (0.70) | MTORRPTORMLST8RICTORMAPKAP1 | |
| SCHEMBL137043 | 0.73 | MTOR (1.00) | MTORRPTORMLST8RICTORMAPKAP1 | |
| SCHEMBL29521551 | 0.73 | MTOR (1.00) | MTORRPTORMLST8RICTORMAPKAP1 | |
| SCHEMBL135776 | 0.72 | MTOR (1.00) | MTORRPTORMLST8RICTORMAPKAP1 | |
| SCHEMBL29521841 | 0.72 | MTOR (1.00) | MTORRPTORMLST8RICTORMAPKAP1 | |
| SCHEMBL31691509 | 0.72 | MTOR (1.00) | MTORRPTORMLST8RICTORMAPKAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2598885-A1 | BIOMARKER ASSAYS FOR DETECTING OR MEASURING INHIBITION OF TOR KINASE ACTIVITY | Signal Pharmaceuticals, LLC (US) | 2013-06-05 | — | — | EP | claimed |
| WO-2012016113-A1 | BIOMARKER ASSAYS FOR DETECTING OR MEASURING INHIBITION OF TOR KINASE ACTIVITY | SIGNAL PHARMACEUTICALS, LLC (US) | 2012-02-02 | — | — | WO | claimed |