Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VDR | P11473 | 12/20 | 0.75 |
| ▸ | MAPT | P10636 | 3/20 | 0.75 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.75 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.75 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.75 |
| ▸ | GC | P02774 | 1/20 | 0.75 |
| ▸ | PGR | P06401 | 1/20 | 0.75 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.75 |
| ▸ | RXRA | P19793 | 1/20 | 0.75 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.75 |
| ▸ | CNR1 | P21554 | 1/20 | 0.75 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.75 |
| ▸ | HTR2C | P28335 | 1/20 | 0.75 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.75 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.75 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.75 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.75 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.75 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.75 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11317373 | 1.00 | VDR (0.75) | VDRMAPTSMN1; SMN2NR1I2ABCB11 | |
| SCHEMBL3728240 | 1.00 | VDR (0.75) | VDRMAPTSMN1; SMN2NR1I2ABCB11 | |
| SCHEMBL11226670 | 1.00 | VDR (0.75) | VDRMAPTSMN1; SMN2NR1I2ABCB11 | |
| SCHEMBL23359104 | 0.92 | VDR (0.77) | VDRMAPTSMN1; SMN2NR1I2ABCB11 | |
| SCHEMBL9001015 | 0.92 | VDR (0.77) | VDRMAPTSMN1; SMN2NR1I2ABCB11 | |
| SCHEMBL23359105 | 0.92 | VDR (0.77) | VDRMAPTSMN1; SMN2NR1I2ABCB11 | |
| SCHEMBL5872989 | 0.91 | VDR (0.76) | VDRMAPTSMN1; SMN2NR1I2ABCB11 | |
| SCHEMBL6402298 | 0.91 | VDR (0.76) | VDRMAPTSMN1; SMN2NR1I2ABCB11 | |
| SCHEMBL5873196 | 0.91 | VDR (0.76) | VDRMAPTSMN1; SMN2NR1I2ABCB11 | |
| SCHEMBL6401347 | 0.91 | VDR (0.76) | VDRMAPTSMN1; SMN2NR1I2ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1830826-A2 | USE OF A COMPOUND THAT ACTIVATES A VITAMIN D RECEPTOR FOR REDUCING INTIMAL HYPERPLASIA, SMOOTH MUSCLE CELL PROLIFERATION AND RESTENOSIS IN MAMMALS | ABBOTT LABORATORIES (US) | 2007-09-12 | — | — | EP | disclosed |
| US-20070134286-A1 | Methods for reducing intimal hyperplasia, smooth muscle cell proliferation and restenosis in mammals | ABBOTT LABORATORIES | 2007-06-14 | — | — | US | disclosed |
| WO-2006060765-A2 | USE OF A COMPOUND THAT ACTIVATES A VITAMIN D RECEPTOR FOR REDUCING INTIMAL HYPERPLASIA, SMOOTH MUSCLE CELL PROLIFERATION AND RESTENOSIS IN MAMMALS | ABBOTT LABORATORIES (US) | 2006-06-08 | — | — | WO | disclosed |
| US-20050192256-A1 | Methods of using vitamin D compounds in the treatment of patients undergoing hemodialysis | MELNICK JOEL Z (US) | 2005-09-01 | — | — | US | disclosed |