Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 17/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | KDM6B | O15054 | 1/20 | 0.45 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.45 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.45 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5302182 | 0.88 | KDM4E (0.49) | HCAR2KDM4EHPGDHSD17B10MEN1 | |
| SCHEMBL14340804 | 0.85 | HCAR2 (0.70) | HCAR2CYP2C8CYP2C9 | |
| SCHEMBL5062205 | 0.85 | HCAR2 (0.64) | HCAR2CYP2C8CYP2C9KDM6BKDM4D | |
| SCHEMBL5293834 | 0.79 | HCAR2 (0.54) | HCAR2CYP2C8CYP2C9KDM6BKDM4D | |
| SCHEMBL5295939 | 0.79 | HCAR2 (0.51) | HCAR2KDM4ECYP2C8CYP2C9KDM6B | |
| SCHEMBL5334252 | 0.78 | HCAR2 (0.49) | HCAR2KDM4ECYP2C8CYP2C9KDM6B | |
| SCHEMBL14609869 | 0.78 | HCAR2 (0.57) | HCAR2CYP2C8CYP2C9KDM6BKDM4D | |
| SCHEMBL5328705 | 0.78 | KDM6B (0.56) | HCAR2MEN1KMT2ACYP2C8CYP2C9 | |
| SCHEMBL14609515 | 0.78 | HCAR2 (0.78) | HCAR2KDM4EHPGDMEN1KMT2A | |
| SCHEMBL5302935 | 0.78 | HCAR2 (0.76) | HCAR2CYP2C8CYP2C9KDM6BKDM4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007015744-A1 | DISUBSTITUTED THIENYL COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2007-02-08 | — | — | WO | claimed |
| WO-2007015744-A1 | DISUBSTITUTED THIENYL COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2007-02-08 | — | — | WO | disclosed |
| WO-2007015744-A1 | DISUBSTITUTED THIENYL COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2007-02-08 | — | — | WO | disclosed |