Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 14/20 | 0.49 |
| ▸ | KDM6B | O15054 | 1/20 | 0.49 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.49 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.49 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5302379 | 0.86 | KDM4E (0.54) | KDM4ETDP1CYP2C9HDAC1HDAC6 | |
| SCHEMBL5062205 | 0.85 | HCAR2 (0.64) | HCAR2KDM6BKDM4DKDM4CEGLN3 | |
| SCHEMBL5293834 | 0.82 | HCAR2 (0.54) | HCAR2KDM6BKDM4DKDM4CEGLN3 | |
| SCHEMBL27521280 | 0.81 | HCAR2 (0.73) | HCAR2KDM4ECYP2C8CYP2C9 | |
| SCHEMBL5301209 | 0.80 | HCAR2 (0.59) | HCAR2HDAC1POLB | |
| SCHEMBL5301758 | 0.80 | HCAR2 (0.52) | HCAR2KDM6BKDM4DKDM4CEGLN3 | |
| SCHEMBL13781545 | 0.80 | HCAR2 (0.63) | HCAR2KDM6BKDM4DKDM4CEGLN3 | |
| SCHEMBL5295939 | 0.79 | HCAR2 (0.51) | HCAR2KDM6BKDM4DKDM4CEGLN3 | |
| SCHEMBL5328705 | 0.78 | KDM6B (0.56) | HCAR2KDM6BKDM4DKDM4CEGLN3 | |
| SCHEMBL14609869 | 0.78 | HCAR2 (0.57) | HCAR2KDM6BKDM4DKDM4CEGLN3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007015744-A1 | DISUBSTITUTED THIENYL COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2007-02-08 | — | — | WO | disclosed |
| WO-2007015744-A1 | DISUBSTITUTED THIENYL COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2007-02-08 | — | — | WO | disclosed |