SCHEMBL5306993

SCHEMBL5306993

CSc1ccc(CN2CCC3(CCN(CC[C@H](NC(=O)C(C)C)c4ccccc4)CC3)C2=O)cc1

nearest known ligand 0.43

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CCR5 P51681 7/20 0.43
CTSB P07858 1/20 0.39
CTSS P25774 1/20 0.39
CTSK P43235 1/20 0.39
UTS2R Q9UKP6 3/20 0.38
SIGMAR1 Q99720 1/20 0.38
MEN1 O00255 2/20 0.36
KMT2A Q03164 2/20 0.36
ATM Q13315 2/20 0.36
KDM4E B2RXH2 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
OPRM1 P35372 1/20 0.36
OPRD1 P41143 1/20 0.36
OPRK1 P41145 1/20 0.36
ALDH1A1 P00352 1/20 0.36
LMNA P02545 1/20 0.36
ROCK2 O75116 1/20 0.36
ROCK1 Q13464 1/20 0.36
RIPK1 Q13546 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL6409219 0.99 CCR5 (0.43) CCR5CTSBCTSSCTSKUTS2R
Hydrochloric Acid SCHEMBL6415642 0.92 CCR5 (0.46) CCR5CTSBCTSSCTSKUTS2R
SCHEMBL6409295 0.90 CCR5 (0.44) CCR5CTSBCTSSCTSKUTS2R
SCHEMBL6409300 0.90 CCR5 (0.44) CCR5CTSBCTSSCTSKUTS2R
Hydrochloric Acid SCHEMBL6410911 0.90 UTS2R (0.46) CCR5CTSBCTSSCTSKUTS2R
Hydrochloric Acid SCHEMBL6415352 0.90 CCR5 (0.43) CCR5CTSBCTSSCTSKUTS2R
Hydrochloric Acid SCHEMBL6417392 0.90 CCR5 (0.44) CCR5CTSBCTSSCTSKMEN1
Hydrochloric Acid SCHEMBL6415357 0.90 CCR5 (0.43) CCR5CTSBCTSSCTSKUTS2R
Hydrochloric Acid SCHEMBL6432231 0.90 CCR5 (0.44) CCR5CTSBCTSSCTSKMEN1
SCHEMBL6409059 0.89 CCR5 (0.47) CCR5SIGMAR1ALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1776362-A1 SPIRO COMPOUNDS AND METHODS FOR THE MODULATION OF CHEMOKINE RECEPTOR ACTIVITY Virochem Pharma Inc. (CA) 2007-04-25 EP disclosed
WO-2005007656-A1 SPIRO COMPOUNDS AND METHODS FOR THE MODULATION OF CHEMOKINE RECEPTOR ACTIVITY VIROCHEM PHARMA INC. (CA) 2005-01-27 WO disclosed