Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 16/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5314824 | 0.91 | CASR (0.38) | CASRCHRM1RXFP1 | |
| SCHEMBL5310887 | 0.88 | LMNA (0.38) | CASR | |
| SCHEMBL5308899 | 0.87 | GNRHR (0.35) | CASRCHRM1POLBRXFP1 | |
| SCHEMBL5311945 | 0.87 | CASR (0.46) | CASRCHRM1POLB | |
| SCHEMBL5310145 | 0.86 | CASR (0.51) | CASRCHRM1 | |
| SCHEMBL5309926 | 0.85 | CASR (0.49) | CASRRXFP1 | |
| SCHEMBL5309986 | 0.85 | CASR (0.49) | CASRCHRM1POLBRXFP1 | |
| SCHEMBL5312353 | 0.84 | CASR (0.54) | CASRPOLBRXFP1 | |
| SCHEMBL5310639 | 0.83 | CASR (0.48) | CASR | |
| SCHEMBL5310323 | 0.82 | CASR (0.52) | CASRCHRM1POLBRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007044796-A2 | PYRIDAZINONE COMPOUNDS AS CALCILYTICS | NPS PHARMACEUTICALS, INC. (US) | 2007-04-19 | — | — | WO | claimed |
| WO-2007044796-A2 | PYRIDAZINONE COMPOUNDS AS CALCILYTICS | NPS PHARMACEUTICALS, INC. (US) | 2007-04-19 | — | — | WO | disclosed |
| WO-2007044796-A2 | PYRIDAZINONE COMPOUNDS AS CALCILYTICS | NPS PHARMACEUTICALS, INC. (US) | 2007-04-19 | — | — | WO | disclosed |