Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 9/20 | 0.58 |
| ▸ | KIT | P10721 | 7/20 | 0.58 |
| ▸ | FLT3 | P36888 | 7/20 | 0.58 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.52 |
| ▸ | CSF1R | P07333 | 3/20 | 0.41 |
| ▸ | FLT1 | P17948 | 3/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.41 |
| ▸ | TEK | Q02763 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.39 |
| ▸ | FEN1 | P39748 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.37 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.37 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5310826 | 0.90 | KDR (0.69) | KDRKITFLT3IKBKECSF1R | |
| SCHEMBL13372708 | 0.88 | KDR (0.53) | KDRKITFLT3IKBKECSF1R | |
| SCHEMBL27636370 | 0.87 | IKBKE (0.67) | KDRKITFLT3IKBKECSF1R | |
| SCHEMBL27657403 | 0.83 | KDR (0.53) | KDRKITFLT3IKBKECSF1R | |
| SCHEMBL422243 | 0.83 | KDR (0.57) | KDRKITFLT3IKBKECSF1R | |
| SCHEMBL420441 | 0.82 | KDR (0.82) | KDRKITFLT3IKBKECSF1R | |
| SCHEMBL27657281 | 0.82 | KDR (0.47) | KDRKITFLT3IKBKECSF1R | |
| SCHEMBL1384424 | 0.80 | KDR (0.73) | KDRKITFLT3IKBKECSF1R | |
| SCHEMBL5251524 | 0.79 | KDR (0.50) | KDRKITFLT3IKBKECSF1R | |
| SCHEMBL421068 | 0.78 | KDR (0.69) | KDRKITFLT3IKBKECSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1850839-A2 | METHODS FOR TREATING OCULAR ANGIOGENESIS, RETINAL EDEMA, RETINAL ISCHEMIA, AND DIABETIC RETINOPATHY USING SELECTIVE RTK INHIBITORS | ALCON INC. (CH) | 2007-11-07 | — | — | EP | claimed |
| WO-2006091801-A2 | METHODS FOR TREATING OCULAR ANGIOGENESIS, RETINAL EDEMA, RETINAL ISCHEMIA, AND DIABETIC RETINOPATHY USING SELECTIVE RTK INHIBITORS | ALCON, INC. (CH) | 2006-08-31 | — | — | WO | claimed |