Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 13/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 1.00 |
| ▸ | LMNA | P02545 | 5/20 | 1.00 |
| ▸ | HPGD | P15428 | 4/20 | 1.00 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.86 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.86 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.86 |
| ▸ | POLB | P06746 | 1/20 | 0.80 |
| ▸ | GAA | P10253 | 2/20 | 0.74 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.74 |
| ▸ | RAB9A | P51151 | 1/20 | 0.74 |
| ▸ | TP53 | P04637 | 1/20 | 0.71 |
| ▸ | NMT1 | P30419 | 4/20 | 0.59 |
| ▸ | NMT2 | O60551 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | RAD52 | P43351 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23575411 | 0.88 | MAPT (0.78) | MAPTALDH1A1LMNAHPGDL3MBTL1 | |
| Hydrochloric Acid SCHEMBL11242122 | 0.86 | MAPT (0.75) | MAPTALDH1A1LMNAHPGDL3MBTL1 | |
| SCHEMBL3788133 | 0.85 | MAPT (0.74) | MAPTALDH1A1LMNAHPGDL3MBTL1 | |
| SCHEMBL13692557 | 0.84 | MAPT (0.81) | MAPTALDH1A1LMNAHPGDL3MBTL1 | |
| SCHEMBL4749614 | 0.84 | MAPT (0.72) | MAPTALDH1A1LMNAHPGDL3MBTL1 | |
| SCHEMBL23575202 | 0.81 | MAPT (0.72) | MAPTALDH1A1LMNAHPGDL3MBTL1 | |
| SCHEMBL13692624 | 0.80 | MAPT (0.77) | MAPTALDH1A1LMNAHPGDL3MBTL1 | |
| SCHEMBL23575157 | 0.80 | MAPT (0.71) | MAPTALDH1A1LMNAHPGDL3MBTL1 | |
| SCHEMBL10673454 | 0.80 | MAPT (0.66) | MAPTALDH1A1LMNAHPGDL3MBTL1 | |
| SCHEMBL13692620 | 0.79 | MAPT (0.74) | MAPTALDH1A1LMNAHPGDL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070148185-A1 | Novel therapeutic target for protozoal diseases | VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY | 2007-06-28 | — | — | US | claimed |
| WO-2007047579-A2 | A NOVEL THERAPEUTIC TARGET FOR PROTOZOAL DISEASES | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (US) | 2007-04-26 | — | — | WO | claimed |
| US-20100075993-A1 | SMALL MOLECULE INHIBITORS AGAINST WEST NILE VIRUS REPLICATION | DREXEL UNIVERSITY (US) | 2010-03-25 | — | — | US | disclosed |
| US-20100075993-A1 | SMALL MOLECULE INHIBITORS AGAINST WEST NILE VIRUS REPLICATION | DREXEL UNIVERSITY (US) | 2010-03-25 | — | — | US | disclosed |
| WO-2007005541-A2 | SMALL MOLECULE INHIBITORS AGAINST WEST NILE VIRUS REPLICATION | PHILADELPHIA HEALTH & EDUCATION CORPORATION, D/B/A DREXEL UNIVERSITY COLLEGE OF MEDICINE (US) | 2007-01-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100075993-A1 | SMALL MOLECULE INHIBITORS AGAINST WEST NILE VIRUS REPLICATION | MAVS, ZC3HAV1, KDM4E | MAPT 910/4885ALDH1A1 4768/4885LMNA 2265/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.