Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.61 |
| ▸ | ANPEP | P15144 | 8/20 | 0.53 |
| ▸ | RNPEP | Q9H4A4 | 4/20 | 0.53 |
| ▸ | DNPEP | Q9ULA0 | 2/20 | 0.53 |
| ▸ | SLC1A3 | P43003 | 3/20 | 0.46 |
| ▸ | SLC1A2 | P43004 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | LAP3 | P28838 | 3/20 | 0.41 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.41 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.39 |
| ▸ | DPP4 | P27487 | 2/20 | 0.38 |
| ▸ | LARS1 | Q9P2J5 | 1/20 | 0.37 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.37 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.37 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7100850 | 1.00 | SLC7A5 (0.61) | SLC7A5ANPEPRNPEPDNPEPSLC1A3 | |
| SCHEMBL5710772 | 0.82 | SLC7A5 (0.58) | SLC7A5ANPEPRNPEPDNPEPSLC1A3 | |
| SCHEMBL18425886 | 0.82 | SLC7A5 (0.58) | SLC7A5ANPEPRNPEPDNPEPSLC1A3 | |
| SCHEMBL7142602 | 0.81 | ALDH1A1 (0.55) | SLC7A5ANPEPRNPEPDNPEPSLC1A3 | |
| SCHEMBL1901280 | 0.81 | ALDH1A1 (0.55) | SLC7A5ANPEPRNPEPDNPEPSLC1A3 | |
| SCHEMBL17943255 | 0.78 | SLC7A5 (0.54) | SLC7A5ANPEPRNPEPDNPEPSLC1A3 | |
| SCHEMBL8088103 | 0.78 | SLC7A5 (0.54) | SLC7A5ANPEPRNPEPDNPEPSLC1A3 | |
| SCHEMBL9393115 | 0.77 | SLC7A5 (0.52) | SLC7A5ANPEPRNPEPDNPEPSLC1A3 | |
| Leucine SCHEMBL25241602 | 0.76 | SLC7A5 (1.00) | SLC7A5RNPEPSLC1A3SLC1A2SLC1A1 | |
| SCHEMBL2617107 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2874997-A2 | NOVEL SIGMA RECEPTOR LIGANDS AND METHODS OF MODULATING CELLULAR PROTEIN HOMEOSTASIS USING SAME | Drexel University (US) | 2015-05-27 | — | — | EP | disclosed |
| WO-2014015157-A2 | NOVEL SIGMA RECEPTOR LIGANDS AND METHODS OF MODULATING CELLULAR PROTEIN HOMEOSTASIS USING SAME | PHILADELPHIA HEALTH & EDUCATION CORPORATION (US) | 2014-01-23 | — | — | WO | disclosed |
| WO-2012016145-A2 | MITOCHONDRIAL APOPTOSIS-INDUCED INFLAMMATION | CEDARS-SINAI MEDICAL CENTER (US) | 2012-02-02 | — | — | WO | disclosed |