Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.38 |
| ▸ | HTR2C | P28335 | 3/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | TPSAB1 | Q15661 | 3/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.32 |
| ▸ | PRKCA | P17252 | 1/20 | 0.32 |
| ▸ | MMP12 | P39900 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL3087552 | 0.77 | PRKCA (0.41) | PRKCAMMP12 | |
| SCHEMBL3088938 | 0.76 | PRKCA (0.40) | PRKCAMMP12 | |
| SCHEMBL3075589 | 0.72 | PRKCA (0.42) | PRKCAMMP12 | |
| SCHEMBL878419 | 0.70 | PRKCA (0.49) | HTR2AHTR2CCNR1PRKCAMMP12 | |
| SCHEMBL3088937 | 0.66 | NR1I2 (0.41) | HTR2APRKCAMMP12 | |
| SCHEMBL3085163 | 0.64 | SCN9A (0.42) | PRKCAMMP12KDM4EHDAC8HDAC6 | |
| SCHEMBL3085391 | 0.63 | NR1I2 (0.46) | PRKCAMMP12 | |
| SCHEMBL804196 | 0.61 | PRKCA (0.51) | PRKCAMMP12KDM4E | |
| Trifluoroacetic Acid SCHEMBL18440248 | 0.60 | HTT (0.36) | — | |
| SCHEMBL5255581 | 0.60 | PRKCA (0.46) | PRKCAMMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807403-A2 | TETRACYCLIC INDOLE DERIVATIVES AS ANTIVIRAL AGENTS | Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. (IT) | 2007-07-18 | — | — | EP | disclosed |
| WO-2006046030-A2 | TETRACYCLIC INDOLE DERIVATIVES AS ANTIVIRAL AGENTS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P ANGELETTI SPA (IT) | 2006-05-04 | — | — | WO | disclosed |