Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 5/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 5/20 | 0.40 |
| ▸ | PRKD2 | Q9BZL6 | 5/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 4/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.40 |
| ▸ | CSNK1A1 | P48729 | 4/20 | 0.40 |
| ▸ | TAOK1 | Q7L7X3 | 4/20 | 0.40 |
| ▸ | CSNK1G2 | P78368 | 3/20 | 0.40 |
| ▸ | MINK1 | Q8N4C8 | 3/20 | 0.40 |
| ▸ | MAP3K20 | Q9NYL2 | 3/20 | 0.40 |
| ▸ | CSNK1G3 | Q9Y6M4 | 3/20 | 0.40 |
| ▸ | FRK | P42685 | 2/20 | 0.40 |
| ▸ | GSK3A | P49840 | 2/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.40 |
| ▸ | MATK | P42679 | 2/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.40 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.40 |
| ▸ | FLT4 | P35916 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5256677 | 0.84 | MAPK14 (0.52) | MKNK1MAPK14MAPK9KCNH2MAPK13 | |
| SCHEMBL5260080 | 0.83 | MAPK14 (0.49) | MAPK14MAPK9GSK3BMAPK13MAPK12 | |
| SCHEMBL5308445 | 0.83 | AURKA (0.39) | MKNK1MAPK14MAPK9CSNK1DPRKD2 | |
| SCHEMBL5257451 | 0.82 | CLK4 (0.58) | MKNK1MAPK14MAPK9CLK4CLK2 | |
| SCHEMBL1554515 | 0.81 | MAPK8 (0.52) | MAPK14MAPK9CSNK1DPRKD2PRKD3 | |
| SCHEMBL5464101 | 0.79 | MAPK14 (0.47) | MAPK14GSK3BKCNH2MAPK13MAPK12 | |
| SCHEMBL5447710 | 0.78 | ADORA3 (0.44) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL14519530 | 0.78 | MAPK8 (0.53) | MKNK1MAPK14MAPK9KCNH2MAPK8 | |
| SCHEMBL5255249 | 0.77 | CDK4 (0.54) | MAPK14MAPK9CSNK1DPRKD2PRKD3 | |
| SCHEMBL5256181 | 0.77 | MAPK14 (0.41) | MAPK14GSK3AGSK3BMAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1500657-B1 | Substituted pyrazoles as P38 kinase inhibitors | SEARLE LLC (US) | 2007-09-19 | — | — | EP | disclosed |
| US-20070078146-A1 | Antiinflamamtory agents; antiarthritic agents; inflammatory bowel disorders; multiple sclerosis; asthma | PHARMACIA CORPORATION | 2007-04-05 | — | — | US | disclosed |
| US-7153959-B2 | treatment of tumor necrosis factor mediated disorders; asthma; inflammatory bowel disease; arthritis | PHARMACIA CORPORATION (US) | 2006-12-26 | — | — | US | disclosed |
| US-7071198-B1 | Antiinflamamtory agents; antiarthritic agents; inflammatory bowel disorders; multiple sclerosis; asthma | PHARMACIA CORPORATION (US) | 2006-07-04 | — | — | US | disclosed |
| US-6979686-B1 | Substituted pyrazoles as p38 kinase inhibitors | PHARMACIA CORPORATION (US) | 2005-12-27 | — | — | US | disclosed |
| EP-1500657-A1 | Substituted pyrazoles as P38 kinase inhibitors | G.D. Searle LLC (US) | 2005-01-26 | — | — | EP | disclosed |
| EP-1144403-B1 | SUBSTITUTED PYRAZOLES AS P38 KINASE INHIBITORS | SEARLE LLC (US) | 2004-10-06 | — | — | EP | disclosed |
| US-20040176433-A1 | treatment of tumor necrosis factor mediated disorders; asthma; inflammatory bowel disease; arthritis | PHARMACIA CORPORATION | 2004-09-09 | — | — | US | disclosed |
| US-6617324-B1 | Phenyl, cyclohexyl and pyridinyl or pyrimidinyl-substituted | G. D. SEARLE & COMPANY | 2003-09-09 | — | — | US | disclosed |
| US-6525059-B1 | Mitogen-activated protein kinases (MAP); | G. D. SEARLE & COMPANY | 2003-02-25 | — | — | US | disclosed |
| US-6514977-B1 | For treating p38 kinase mediated disorders | G.D. SEARLE & COMPANY | 2003-02-04 | — | — | US | disclosed |
| US-6423713-B1 | Substituted pyrazoles as p38 kinase inhibitors | G. D. SEARLE & COMPANY | 2002-07-23 | — | — | US | disclosed |
| CN-1342157-A | Substituted pyrazoles ASP38 kinase inhibitors | SEARLE & CO (US) | 2002-03-27 | — | — | CN | disclosed |
| EP-1144403-A1 | SUBSTITUED PYRAZOLES AS P38 KINASE INHIBITORS | G.D. SEARLE & CO. (US) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000031063-A1 | SUBSTITUTED PYRAZOLES AS p38 KINASE INHIBITORS | G.D. SEARLE & CO. (US) | 2000-06-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040176433-A1 | treatment of tumor necrosis factor mediated disorders; asthma; inflammatory bowel disease; arthritis | MAPK1, IL1R1, TNF | MKNK1 563/4885MAPK14 12/4885MAPK9 76/4885 |
| US-20070078146-A1 | Antiinflamamtory agents; antiarthritic agents; inflammatory bowel disorders; multiple sclerosis; asthma | MAPK1, MAPK3, MAPK4 | MKNK1 523/4885MAPK14 7/4885MAPK9 38/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.