Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 9/20 | 0.56 |
| ▸ | PDE4A | P27815 | 12/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.51 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14244189 | 0.94 | RECQL (0.60) | PDE4BPDE4ARECQLPDE4CPDE4D | |
| SCHEMBL3976102 | 0.86 | PDE4B (0.57) | PDE4BPDE4ARECQLPDE4CPDE4D | |
| SCHEMBL2958828 | 0.84 | RECQL (0.60) | PDE4BPDE4ARECQLPDE4CPDE4D | |
| SCHEMBL5703607 | 0.84 | PDE4B (0.56) | PDE4BPDE4ARECQLPDE4CPDE4D | |
| SCHEMBL2956981 | 0.84 | CSNK2A1 (0.66) | PDE4BPDE4ARECQLPDE4CPDE4D | |
| SCHEMBL5610571 | 0.82 | RECQL (0.61) | PDE4BPDE4ARECQLPDE4CPDE4D | |
| SCHEMBL7375826 | 0.82 | PDE4B (0.57) | PDE4BPDE4ARECQLPDE4CPDE4D | |
| SCHEMBL7353001 | 0.82 | KDM4E (0.66) | PDE4BPDE4ARECQLPDE4CPDE4D | |
| SCHEMBL13317191 | 0.82 | RECQL (0.61) | PDE4BPDE4ARECQLPDE4CPDE4D | |
| SCHEMBL7023339 | 0.81 | PDE4B (0.55) | PDE4BPDE4ARECQLPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0799823-B1 | 1,2-Diphenylpyrrole derivatives, their preparation and their therapeutic uses | DAIICHI SANKYO CO LTD (JP) | 2007-10-31 | — | — | EP | disclosed |
| CN-1301982-C | Compounds and methods for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids | SMITHKLINE BEECHAM CORP (US) | 2007-02-28 | — | — | CN | disclosed |
| EP-1524268-B1 | Compounds and method for preparing sustituted 4-phenyl-4-cyanocyclohexanoic acids | SMITHKLINE BEECHAM CORP (US) | 2007-01-17 | — | — | EP | disclosed |
| US-RE39420-E1 | 1,2-Diphenylpyrrole derivatives, their preparation and their therapeutic uses | SANKYO COMPANY, LIMITED (JP) | 2006-12-05 | — | — | US | disclosed |
| CN-1854131-A | Compounds and method for preparing sustituted 4-phenyl-4-cyanocyclohexanoic acids | SMITHKLINE BEECHAM CORP (US) | 2006-11-01 | — | — | CN | disclosed |
| EP-1295869-B1 | Compounds and method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids | SMITHKLINE BEECHAM CORP (US) | 2005-07-27 | — | — | EP | disclosed |
| US-6919455-B2 | Purine derivative dihydrate, drugs containing the same as the active ingredient and intermediate in the production thereof | MITSUBISHI CHEMICAL CORPORATION (JP) | 2005-07-19 | — | — | US | disclosed |
| EP-1524268-A1 | Compounds and method for preparing sustituted 4-phenyl-4-cyanocyclohexanoic acids | SmithKline Beecham Corporation (US) | 2005-04-20 | — | — | EP | disclosed |
| CN-1192025-C | Method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids | SMITHKLINE BEECHAM CORP (US) | 2005-03-09 | — | — | CN | disclosed |
| EP-1043930-A4 | METHOD FOR PREPARING SUBSTITUTED 4-PHENYL-4-CYANOCYCLOHEXANOIC ACIDS | SMITHKLINE BEECHAM CORP (US) | 2004-09-15 | — | — | EP | disclosed |
| EP-0799823-A1 | 1,2-Diphenylpyrrole derivatives, their preparation and their therapeutic uses | SANKYO COMPANY LIMITED (JP) | 1997-10-08 | — | — | EP | disclosed |
| EP-0796093-A1 | COMPOUNDS FOR AND METHOD OF INHIBITING PHOSPHODIESTERASE IV | Euroceltique S.A. (LU) | 1997-09-24 | — | — | EP | disclosed |
| EP-0640070-B1 | STYRYL DERIVATIVES, THEIR PREPARATION AND USE AS PDE-IV INHIBITORS | CELLTECH THERAPEUTICS LTD (GB) | 1997-09-10 | — | — | EP | disclosed |
| US-5665737-A | PHOSPHODIESTERASE INHIBITORS | EURO-CELTIQUE, S.A. (LU) | 1997-09-09 | — | — | US | disclosed |
| EP-0785927-A1 | NOVEL BENZOXAZOLES | Euroceltique S.A. (LU) | 1997-07-30 | — | — | EP | disclosed |
| EP-0766670-A1 | TRI-SUBSTITUTED PHENYL DERIVATIVES USEFUL AS PDE IV INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1997-04-09 | — | — | EP | disclosed |
| US-5591776-A | Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV | EURO-CELTIQUE, S.A. (LU) | 1997-01-07 | — | — | US | disclosed |
| WO-1996021435-A1 | COMPOUNDS FOR AND METHOD OF INHIBITING PHOSPHODIESTERASE IV | EURO-CELTIQUE, S.A. (LU) | 1996-07-18 | — | — | WO | disclosed |
| WO-1996011917-A1 | NOVEL BENZOXAZOLES | EURO-CELTIQUE, S.A. (LU) | 1996-04-25 | — | — | WO | disclosed |
| WO-1995035284-A1 | TRI-SUBSTITUTED PHENYL DERIVATIVES USEFUL AS PDE IV INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1995-12-28 | — | — | WO | disclosed |