Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 11/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | PDE4A | P27815 | 11/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7325038 | 0.87 | PDE4B (0.57) | PDE4BRECQLPDE4APDE4CPDE4D | |
| SCHEMBL7448551 | 0.86 | PDE4A (0.62) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7326058 | 0.85 | RECQL (0.51) | PDE4BRECQLPDE4APDE4CPDE4D | |
| SCHEMBL7325727 | 0.85 | RECQL (0.51) | PDE4BRECQLPDE4APDE4CPDE4D | |
| SCHEMBL7361212 | 0.85 | RECQL (0.51) | PDE4BRECQLPDE4APDE4CPDE4D | |
| SCHEMBL7326065 | 0.85 | RECQL (0.51) | PDE4BRECQLPDE4APDE4CPDE4D | |
| SCHEMBL3976102 | 0.83 | PDE4B (0.57) | PDE4BRECQLPDE4APDE4CPDE4D | |
| SCHEMBL5350500 | 0.83 | PDE4B (0.53) | PDE4BPDE4APDE4CPDE4DPOLB | |
| SCHEMBL5350503 | 0.83 | PDE4B (0.53) | PDE4BPDE4APDE4CPDE4DPOLB | |
| SCHEMBL7328806 | 0.82 | PDE4B (0.53) | PDE4BRECQLPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0819122-B1 | 1,3-DIHYDRO-1-(PHENYLALKYL)-2H-IMIDAZOL-2-ONE DERIVATIVES HAVING PDEIV AND CYTOKINE ACTIVITY | JANSSEN PHARMACEUTICA NV (BE) | 2002-03-06 | — | — | EP | disclosed |
| EP-0832071-A1 | 1,3-DIHYDRO-2H-IMIDAZOL-2-ONE DERIVATIVES HAVING PDE IV AND CYTOKININ INHIBITING ACTIVITY | JANSSEN PHARMACEUTICA N.V. (BE) | 1998-04-01 | — | — | EP | disclosed |
| WO-1996031487-A1 | 1,3-DIHYDRO-2H-IMIDAZOL-2-ONE DERIVATIVES HAVING PDE IV AND CYTOKININ INHIBITING ACTIVITY | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-10-10 | — | — | WO | disclosed |