Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 2/20 | 0.68 |
| ▸ | POLB | P06746 | 2/20 | 0.67 |
| ▸ | CDC25B | P30305 | 2/20 | 0.59 |
| ▸ | CDC25A | P30304 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | LTC4S | Q16873 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | FNTA | P49354 | 1/20 | 0.51 |
| ▸ | FNTB | P49356 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 6-Benzoyl-3-Methylbenzoic Acid SCHEMBL5484402 | 0.98 | AKR1C3 (0.66) | AKR1C3POLBCDC25BCDC25AHSD17B10 | |
| SCHEMBL9217336 | 0.93 | AKR1C3 (0.68) | AKR1C3POLBCDC25BCDC25AHSD17B10 | |
| SCHEMBL28384878 | 0.92 | AKR1C3 (0.61) | AKR1C3POLBKDM4ENPSR1MEN1 | |
| SCHEMBL4638917 | 0.86 | AKR1C3 (0.54) | AKR1C3POLBKDM4ENPSR1TP53 | |
| SCHEMBL5484397 | 0.86 | AKR1C3 (0.54) | AKR1C3POLBKDM4ENPSR1MEN1 | |
| SCHEMBL1821601 | 0.84 | NR4A1 (0.62) | AKR1C3POLBCDC25BCDC25AHSD17B10 | |
| SCHEMBL16363711 | 0.84 | POLB (0.60) | AKR1C3POLBCDC25BCDC25AHSD17B10 | |
| SCHEMBL9327289 | 0.84 | AKR1C3 (0.51) | AKR1C3POLBKDM4ENPSR1MEN1 | |
| SCHEMBL11587451 | 0.83 | AKR1C3 (0.70) | AKR1C3POLBCDC25BCDC25AHSD17B10 | |
| SCHEMBL29356028 | 0.83 | NPSR1 (0.60) | AKR1C3POLBNPSR1ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4292142-A | MIXTURE OF PHTHALIC ANHYDRIDE AND MALEIC ANHYDRIDE | INTERNATIONAL SYNTHETIC RUBBER CO., LTD. (GB) | 1981-09-29 | — | — | US | claimed |
| US-20230278989-A1 | ISOINDOLINONE INHIBITORS OF THE MDM2-P53 INTERACTION AND PROCESS FOR MAKING THEM | ASTEX THERAPEUTICS LIMITED (GB) | 2023-09-07 | — | — | US | disclosed |
| US-10544132-B2 | Isoindolinone inhibitors of the MDM2-p53 interaction having anticancer activity | ASTEX THERAPEUTICS LIMITED (GB) | 2020-01-28 | — | — | US | disclosed |
| US-20190016708-A1 | ISOINDOLINONE INHIBITORS OF THE MDM2-P53 INTERACTION HAVING ANTICANCER ACTIVITY | ASTEX THERAPEUTICS LIMITED (GB) | 2019-01-17 | — | — | US | disclosed |
| WO-2007044184-A1 | WATER SOLUBLE PHOTOINITIATOR | ALBEMARLE CORPORATION (US) | 2007-04-19 | — | — | WO | disclosed |
| US-20070066837-A1 | Podophyllotoxin derivatives as antitumor agents | RANBAXY LABORATORIES LIMITED (IN) | 2007-03-22 | — | — | US | disclosed |
| EP-1599485-A2 | PODOPHYLLOTOXIN DERIVATIVES AS ANTITUMOR AGENTS | RANBAXY LABORATORIES, LTD. (IN) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004073375-A2 | PODOPHYLLOTOXIN DERIVATIVES AS ANTITUMOR AGENTS | RANBAXY LABORATORIES LIMITED (IN) | 2004-09-02 | — | — | WO | disclosed |
| EP-0569457-B1 | USE OF THIAZOLO-[2,3-A]ISOINDOLE DERIVATIVES AS ANTIVIRAL MEDICAMENTS AND NOVEL THIAZOLO- [2,3-A]ISOINDOLE DERIVATIVES | BOEHRINGER MANNHEIM GMBH (DE) | 1995-06-14 | — | — | EP | disclosed |
| WO-1992013863-A1 | USE OF THIAZOLO-[2,3-A]ISOINDOLE DERIVATIVES AS ANTIVIRAL MEDICAMENTS AND NOVEL THIAZOLO-[2,3-A]ISOINDOLE DERIVATIVES | BOEHRINGER MANNHEIM GMBH (DE) | 1992-08-20 | — | — | WO | disclosed |
| EP-0210415-B1 | PROCESS FOR PRODUCING CRYSTALLINE ORGANIC MATERIALS | BASF Aktiengesellschaft (DE) | 1991-10-30 | — | — | EP | disclosed |
| US-4769200-A | EXTRUSION PULVERIZED MOLTEN MATERIAL THROUGH TWIN-SCREW EXTRUDER IN WHICH SCREWS ROTATE IN SAME DIRECTION; EJECTION TO LOW PRESSURE ZONE, COOLING, AND COMMINUTION; SHELF LIFE | BASF AKTIENGESELLSCHAFT (DE) | 1988-09-06 | — | — | US | disclosed |
| EP-0210415-A2 | Process for producing crystalline organic materials | BASF Aktiengesellschaft (DE) | 1987-02-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10544132-B2 | Isoindolinone inhibitors of the MDM2-p53 interaction having anticancer activity | TP53, MDM2, TP53BP1 | AKR1C3 2044/4885POLB 1106/4885CDC25B 65/4885 |
| US-20070066837-A1 | Podophyllotoxin derivatives as antitumor agents | DIMT1, CYP51A1, MAGT1 | AKR1C3 1820/4885POLB 3725/4885CDC25B 88/4885 |
| US-20230278989-A1 | ISOINDOLINONE INHIBITORS OF THE MDM2-P53 INTERACTION AND PROCESS FOR MAKING THEM | MDM2, TP53, TP53BP1 | AKR1C3 1327/4885POLB 874/4885CDC25B 70/4885 |
| US-20190016708-A1 | ISOINDOLINONE INHIBITORS OF THE MDM2-P53 INTERACTION HAVING ANTICANCER ACTIVITY | TP53, MDM2, TP53BP1 | AKR1C3 2044/4885POLB 1106/4885CDC25B 65/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.