Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.46 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28384878 | 0.89 | AKR1C3 (0.61) | AKR1C3POLBNPSR1TP53GAA | |
| 6-Benzoyl-3-Methylbenzoic Acid SCHEMBL5309754 | 0.86 | AKR1C3 (0.68) | AKR1C3POLBNPSR1TP53MAPT | |
| 6-Benzoyl-3-Methylbenzoic Acid SCHEMBL5484402 | 0.84 | AKR1C3 (0.66) | AKR1C3POLBNPSR1TP53GAA | |
| SCHEMBL4638917 | 0.83 | AKR1C3 (0.54) | AKR1C3POLBNPSR1TP53GAA | |
| SCHEMBL9217336 | 0.82 | AKR1C3 (0.68) | AKR1C3POLBNPSR1TP53MAPT | |
| SCHEMBL302204 | 0.81 | CSNK2A1 (0.48) | POLBMAPTHTTNPC1MAPK1 | |
| SCHEMBL10424856 | 0.81 | TDP1 (0.50) | GAAMAPTHTTNPC1MAPK1 | |
| SCHEMBL257273 | 0.81 | TP53 (0.60) | AKR1C3POLBNPSR1TP53GAA | |
| SCHEMBL95646 | 0.81 | TP53 (0.57) | AKR1C3POLBNPSR1TP53GAA | |
| SCHEMBL9327289 | 0.81 | AKR1C3 (0.51) | AKR1C3POLBNPSR1TP53GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070066837-A1 | Podophyllotoxin derivatives as antitumor agents | RANBAXY LABORATORIES LIMITED (IN) | 2007-03-22 | — | — | US | disclosed |
| EP-1599485-A2 | PODOPHYLLOTOXIN DERIVATIVES AS ANTITUMOR AGENTS | RANBAXY LABORATORIES, LTD. (IN) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004073375-A2 | PODOPHYLLOTOXIN DERIVATIVES AS ANTITUMOR AGENTS | RANBAXY LABORATORIES LIMITED (IN) | 2004-09-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070066837-A1 | Podophyllotoxin derivatives as antitumor agents | DIMT1, CYP51A1, MAGT1 | AKR1C3 1820/4885POLB 3725/4885NPSR1 4056/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.