Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 13/20 | 0.69 |
| ▸ | MAPK8 | P45983 | 5/20 | 0.69 |
| ▸ | CDC7 | O00311 | 2/20 | 0.69 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.69 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.60 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.60 |
| ▸ | JAK2 | O60674 | 2/20 | 0.53 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.47 |
| ▸ | PAK4 | O96013 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | CDK9 | P50750 | 1/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | MELK | Q14680 | 1/20 | 0.47 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.47 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.47 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1203456 | 0.88 | MAPK8 (0.61) | AURKAMAPK8CDC7ALKAURKB | |
| SCHEMBL3098316 | 0.86 | AURKA (0.66) | AURKAMAPK8CDC7ALKPBRM1 | |
| SCHEMBL1203432 | 0.86 | ULK1 (0.58) | AURKAMAPK8CDC7ALKAURKB | |
| SCHEMBL656020 | 0.84 | AURKA (0.50) | AURKAMAPK8CDC7ALKAURKB | |
| SCHEMBL15492024 | 0.84 | AURKA (0.63) | AURKAMAPK8CDC7ALKPBRM1 | |
| SCHEMBL30039325 | 0.84 | AURKA (0.63) | AURKAMAPK8CDC7ALKPBRM1 | |
| SCHEMBL15492010 | 0.84 | AURKA (0.63) | AURKAMAPK8CDC7ALKPBRM1 | |
| SCHEMBL1203547 | 0.83 | AURKA (0.49) | AURKAMAPK8CDC7ALKAURKB | |
| SCHEMBL1202883 | 0.82 | CDC25B (0.52) | AURKAMAPK8CDC7ALK | |
| SCHEMBL1203944 | 0.82 | AURKA (0.48) | AURKAMAPK8CDC7ALKAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007048064-A2 | AMINO-PYRIMIDINES AS CASEIN KINASE II (CK2) MODULATORS | EXELIXIS, INC. (US) | 2007-04-26 | — | — | WO | claimed |
| US-9597329-B2 | Aurora kinase inhibitors and methods of making and using thereof | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC (US) | 2017-03-21 | — | — | US | disclosed |
| US-20170000787-A1 | AURORA KINASE INHIBITORS AND METHODS OF MAKING AND USING THEREOF | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2017-01-05 | — | — | US | disclosed |
| US-9249124-B2 | Aurora kinase inhibitors and methods of making and using thereof | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2016-02-02 | — | — | US | disclosed |
| US-20140057913-A1 | AURORA KINASE INHIBITORS AND METHODS OF MAKING AND USING THEREOF | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2014-02-27 | — | — | US | disclosed |
| WO-2007048064-A2 | AMINO-PYRIMIDINES AS CASEIN KINASE II (CK2) MODULATORS | EXELIXIS, INC. (US) | 2007-04-26 | — | — | WO | disclosed |
| WO-2007048064-A2 | AMINO-PYRIMIDINES AS CASEIN KINASE II (CK2) MODULATORS | EXELIXIS, INC. (US) | 2007-04-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140057913-A1 | AURORA KINASE INHIBITORS AND METHODS OF MAKING AND USING THEREOF | AURKC, AURKA, AURKB | AURKA 2/4885MAPK8 558/4885CDC7 6/4885 |
| US-20170000787-A1 | AURORA KINASE INHIBITORS AND METHODS OF MAKING AND USING THEREOF | AURKC, AURKA, AURKB | AURKA 2/4885MAPK8 558/4885CDC7 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.