Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 9/20 | 0.48 |
| ▸ | PRKCA | P17252 | 4/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | PRKCB | P05771 | 2/20 | 0.41 |
| ▸ | PRKCH | P24723 | 1/20 | 0.41 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.41 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.41 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5254197 | 0.89 | GSK3B (0.50) | GSK3BPRKCACDK2PRKCBPRKCH | |
| Hydrochloric Acid SCHEMBL5253479 | 0.85 | GSK3B (0.47) | GSK3BPRKCACDK2PRKCBPRKCH | |
| Hydrochloric Acid SCHEMBL5258346 | 0.85 | GSK3B (0.47) | GSK3BPRKCACDK2PRKCBPRKCH | |
| Hydrochloric Acid SCHEMBL5255154 | 0.84 | GSK3B (0.48) | GSK3BPRKCACDK2PRKCBPRKCH | |
| Hydrochloric Acid SCHEMBL5252575 | 0.82 | GSK3B (0.46) | GSK3BPRKCAPRKCBPRKCHPRKCE | |
| Hydrochloric Acid SCHEMBL5252759 | 0.82 | GSK3B (0.44) | GSK3BPRKCACDK2PRKCBPRKCH | |
| SCHEMBL5256883 | 0.77 | GSK3B (0.42) | GSK3BPRKCAPRKCBPRKCHPRKCE | |
| SCHEMBL5252064 | 0.77 | GSK3B (0.41) | GSK3BPRKCACDK2PRKCBPRKCH | |
| SCHEMBL5257697 | 0.77 | GSK3B (0.40) | GSK3BPRKCACDK2PRKCBPRKCH | |
| SCHEMBL5253874 | 0.77 | GSK3B (0.41) | GSK3BPRKCAPRKCBPRKCHPRKCE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487822-B1 | PYRROLE-2,5-DIONE DERIVATIVES AND THEIR USE AS GSK-3 INHIBITORS | LILLY CO ELI (US) | 2007-08-01 | — | — | EP | disclosed |