Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 15/20 | 0.40 |
| ▸ | GSK3A | P49840 | 4/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | PRKCB | P05771 | 1/20 | 0.34 |
| ▸ | PRKCA | P17252 | 1/20 | 0.34 |
| ▸ | PRKCH | P24723 | 1/20 | 0.34 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.34 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.34 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | QPCT | Q16769 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5252064 | 0.97 | GSK3B (0.41) | GSK3BGSK3ACDK2PRKCBPRKCA | |
| SCHEMBL5253874 | 0.92 | GSK3B (0.41) | GSK3BGSK3ACNR2PRKCBPRKCA | |
| SCHEMBL5256883 | 0.91 | GSK3B (0.42) | GSK3BGSK3APRKCBPRKCAPRKCH | |
| SCHEMBL5252434 | 0.91 | SIGMAR1 (0.45) | GSK3BGSK3AMAOAMAOB | |
| SCHEMBL5255165 | 0.90 | SIGMAR1 (0.45) | GSK3BGSK3AMAOAMAOB | |
| SCHEMBL5252381 | 0.89 | GSK3B (0.40) | GSK3BGSK3ACNR2QPCT | |
| SCHEMBL5260122 | 0.87 | GSK3B (0.37) | GSK3BGSK3ACNR2QPCT | |
| SCHEMBL5252221 | 0.87 | SIGMAR1 (0.47) | GSK3BGSK3AMAOBQPCT | |
| SCHEMBL27598059 | 0.85 | GSK3B (0.37) | GSK3BGSK3ACNR2QPCT | |
| SCHEMBL5255984 | 0.84 | SIGMAR1 (0.44) | GSK3BGSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487822-B1 | PYRROLE-2,5-DIONE DERIVATIVES AND THEIR USE AS GSK-3 INHIBITORS | LILLY CO ELI (US) | 2007-08-01 | — | — | EP | disclosed |
| CN-1639152-A | Pyrrole-2, 5-dione derivatives and their use as GSK-3 inhibitors | LILLY CO ELI (US) | 2005-07-13 | — | — | CN | disclosed |