Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3CHRM1CHRM2CHRM3CHRM4ESR1ESR2GABRA1GABRB1GABRG2GBA1HRH1HTR1DHTR2AOPRD1OPRK1OPRM1SLC6A2SLC6A3TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Cadaverine Tartrate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 13/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 19/20 | 0.43 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cadaverine Tartrate SCHEMBL3757 | 0.85 | SLC6A4 (0.64) | SLC6A4SLC6A2 | |
| Sulfuric Acid SCHEMBL5308022 | 0.74 | SLC6A4 (0.60) | SLC6A4SLC6A2 | |
| SCHEMBL29975150 | 0.64 | SLC6A2 (0.50) | SLC6A4SLC6A2 | |
| SCHEMBL23761083 | 0.64 | SLC6A2 (0.50) | SLC6A4SLC6A2 | |
| SCHEMBL23521649 | 0.64 | SLC6A2 (0.50) | SLC6A4SLC6A2 | |
| SCHEMBL23521650 | 0.64 | SLC6A2 (0.50) | SLC6A4SLC6A2 | |
| Duloxetine SCHEMBL3134789 | 0.64 | SLC6A2 (0.82) | SLC6A4SLC6A2 | |
| SCHEMBL3282 | 0.63 | SLC2A1 (0.43) | SLC6A4SLC6A2 | |
| SCHEMBL3758 | 0.63 | SLC6A4 (0.41) | SLC6A4SLC6A2 | |
| SCHEMBL5083145 | 0.63 | SLC6A4 (0.46) | SLC6A4SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007041463-A2 | ELECTRICAL DEVICES AND ANTI-SCARRING DRUG COMBINATIONS | COMBINATORX, INCORPORATED (US) | 2007-04-12 | — | — | WO | disclosed |
| WO-2007041584-A2 | IMPLANTABLE SENSORS, IMPLANTABLE PUMPS, AND ANTI-SCARRING DRUG COMBINATIONS | COMBINATORX, INCORPORATED (US) | 2007-04-12 | — | — | WO | disclosed |