Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 17/20 | 0.60 |
| ▸ | PIK3CA | P42336 | 11/20 | 0.60 |
| ▸ | RPTOR | Q8N122 | 9/20 | 0.49 |
| ▸ | MLST8 | Q9BVC4 | 9/20 | 0.49 |
| ▸ | RICTOR | Q6R327 | 2/20 | 0.49 |
| ▸ | MAPKAP1 | Q9BPZ7 | 2/20 | 0.49 |
| ▸ | CSF1R | P07333 | 2/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | FLT4 | P35916 | 1/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.42 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL531036 | 1.00 | MTOR (0.60) | MTORPIK3CARPTORMLST8RICTOR | |
| SCHEMBL532015 | 0.85 | MTOR (0.54) | MTORPIK3CARPTORMLST8RICTOR | |
| SCHEMBL29522670 | 0.81 | MTOR (0.90) | MTORPIK3CARPTORMLST8RICTOR | |
| SCHEMBL138384 | 0.81 | MTOR (0.90) | MTORPIK3CARPTORMLST8RICTOR | |
| SCHEMBL152837 | 0.81 | MTOR (0.90) | MTORPIK3CARPTORMLST8RICTOR | |
| SCHEMBL154892 | 0.81 | MTOR (0.90) | MTORPIK3CARPTORMLST8RICTOR | |
| SCHEMBL29522087 | 0.81 | MTOR (0.90) | MTORPIK3CARPTORMLST8RICTOR | |
| SCHEMBL530988 | 0.81 | MTOR (0.71) | MTORPIK3CARPTORMLST8RICTOR | |
| SCHEMBL530735 | 0.76 | MTOR (0.68) | MTORPIK3CARPTORMLST8RICTOR | |
| SCHEMBL531946 | 0.75 | MTOR (0.46) | MTORPIK3CARPTORMLST8RICTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2598885-A1 | BIOMARKER ASSAYS FOR DETECTING OR MEASURING INHIBITION OF TOR KINASE ACTIVITY | Signal Pharmaceuticals, LLC (US) | 2013-06-05 | — | — | EP | disclosed |
| WO-2012016113-A1 | BIOMARKER ASSAYS FOR DETECTING OR MEASURING INHIBITION OF TOR KINASE ACTIVITY | SIGNAL PHARMACEUTICALS, LLC (US) | 2012-02-02 | — | — | WO | disclosed |