Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 17/20 | 0.68 |
| ▸ | PIK3CA | P42336 | 12/20 | 0.68 |
| ▸ | RPTOR | Q8N122 | 9/20 | 0.59 |
| ▸ | MLST8 | Q9BVC4 | 9/20 | 0.59 |
| ▸ | RICTOR | Q6R327 | 2/20 | 0.59 |
| ▸ | MAPKAP1 | Q9BPZ7 | 2/20 | 0.59 |
| ▸ | CSF1R | P07333 | 2/20 | 0.59 |
| ▸ | SYK | P43405 | 3/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | FLT4 | P35916 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.41 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL530988 | 0.92 | MTOR (0.71) | MTORPIK3CARPTORMLST8RICTOR | |
| SCHEMBL138628 | 0.82 | MTOR (0.98) | MTORPIK3CARPTORMLST8RICTOR | |
| SCHEMBL29522256 | 0.82 | MTOR (0.98) | MTORPIK3CARPTORMLST8RICTOR | |
| SCHEMBL138732 | 0.81 | MTOR (1.00) | MTORPIK3CARPTORMLST8RICTOR | |
| SCHEMBL29521669 | 0.81 | MTOR (1.00) | MTORPIK3CARPTORMLST8RICTOR | |
| SCHEMBL530610 | 0.81 | MTOR (0.61) | MTORPIK3CARPTORMLST8RICTOR | |
| SCHEMBL530692 | 0.80 | MTOR (0.58) | MTORPIK3CARPTORMLST8RICTOR | |
| SCHEMBL138631 | 0.78 | MTOR (0.91) | MTORPIK3CARPTORMLST8RICTOR | |
| SCHEMBL29522011 | 0.78 | MTOR (0.91) | MTORPIK3CARPTORMLST8RICTOR | |
| SCHEMBL532015 | 0.77 | MTOR (0.54) | MTORPIK3CARPTORMLST8RICTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2598885-A1 | BIOMARKER ASSAYS FOR DETECTING OR MEASURING INHIBITION OF TOR KINASE ACTIVITY | Signal Pharmaceuticals, LLC (US) | 2013-06-05 | — | — | EP | claimed |
| WO-2012016113-A1 | BIOMARKER ASSAYS FOR DETECTING OR MEASURING INHIBITION OF TOR KINASE ACTIVITY | SIGNAL PHARMACEUTICALS, LLC (US) | 2012-02-02 | — | — | WO | claimed |