Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.53 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.53 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.53 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.52 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.51 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12505085 | 0.88 | TRPV1 (0.53) | HPGDHDAC3HDAC1HDAC4HDAC7 | |
| SCHEMBL17954341 | 0.87 | TRPV1 (0.51) | HPGDHDAC3HDAC1HDAC4HDAC7 | |
| SCHEMBL30444584 | 0.83 | EPHX2 (0.61) | HDAC3HDAC1HDAC4HDAC7HDAC2 | |
| SCHEMBL30445391 | 0.83 | EPHX2 (0.61) | HDAC3HDAC1HDAC4HDAC7HDAC2 | |
| SCHEMBL6115263 | 0.79 | TRPV1 (0.58) | TRPV1MEN1KMT2A | |
| SCHEMBL6114751 | 0.79 | TRPV1 (0.58) | TRPV1MEN1KMT2A | |
| SCHEMBL6114625 | 0.79 | TRPV1 (0.58) | TRPV1MEN1KMT2A | |
| SCHEMBL6114969 | 0.79 | TRPV1 (0.58) | TRPV1MEN1KMT2A | |
| SCHEMBL6114605 | 0.79 | TRPV1 (0.58) | TRPV1MEN1KMT2A | |
| SCHEMBL6114660 | 0.79 | TRPV1 (0.58) | TRPV1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2597955-A1 | QUINOLINE DERIVATIVES AND MELK INHIBITORS CONTAINING THE SAME | OncoTherapy Science, Inc. (JP) | 2013-06-05 | — | — | EP | disclosed |
| WO-2012016082-A1 | QUINOLINE DERIVATIVES AND MELK INHIBITORS CONTAINING THE SAME | ONCOTHERAPY SCIENCE, INC. (JP) | 2012-02-02 | — | — | WO | disclosed |