Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 10/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.37 |
| ▸ | TOP2A | P11388 | 1/20 | 0.37 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5380546 | 0.84 | HIF1A (0.41) | HIF1ATDP1EGLN3TOP2AEGLN1 | |
| SCHEMBL5314833 | 0.84 | MEN1 (0.49) | HIF1ATDP1EGLN3EGLN1KDM4E | |
| SCHEMBL5311760 | 0.83 | HIF1A (0.40) | HIF1ATDP1EGLN3TOP2AEGLN1 | |
| SCHEMBL5306650 | 0.82 | MEN1 (0.47) | HIF1ATDP1EGLN3EGLN1KDM4E | |
| SCHEMBL5312400 | 0.81 | MEN1 (0.48) | HIF1ATDP1EGLN3TOP2AEGLN1 | |
| SCHEMBL5307090 | 0.81 | HIF1A (0.39) | HIF1ATDP1EGLN3EGLN1NPC1 | |
| SCHEMBL5305537 | 0.81 | TDP1 (0.45) | HIF1ATDP1TOP2AEGLN1MEN1 | |
| SCHEMBL5309478 | 0.81 | HIF1A (0.39) | HIF1ATDP1EGLN3EGLN1NPC1 | |
| SCHEMBL5305557 | 0.80 | HIF1A (0.43) | HIF1ATDP1EGLN3TOP2AEGLN1 | |
| SCHEMBL5313516 | 0.79 | EGLN3 (0.43) | HIF1ATDP1EGLN3TOP2AEGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007038571-A2 | PROLYL HYDROXYLASE ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-04-05 | — | — | WO | claimed |