Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 4/20 | 0.40 |
| ▸ | HTR2B | P41595 | 5/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.36 |
| ▸ | RBP4 | P02753 | 1/20 | 0.35 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.35 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.34 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.34 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.34 |
| ▸ | RAF1 | P04049 | 3/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5151958 | 0.87 | TRPC3 (0.43) | TBK1 | |
| SCHEMBL5138151 | 0.74 | GRIN2B (0.42) | HTR2BUSP30 | |
| SCHEMBL5137949 | 0.73 | TGFBR1 (0.39) | TBK1MAPK14CSNK1A1CSNK1DRPS6KA3 | |
| SCHEMBL5084560 | 0.72 | TGFBR1 (0.54) | MAPK14BRAFTGFBR1 | |
| SCHEMBL5091521 | 0.72 | KDR (0.40) | MAPK9MAPK11MAPK14BRAFTGFBR1 | |
| SCHEMBL5139926 | 0.71 | TGFBR1 (0.35) | TBK1MAPK14TGFBR1 | |
| SCHEMBL5188298 | 0.70 | TGFBR1 (0.49) | TBK1USP30MAPK13MAPK9MAPK12 | |
| SCHEMBL4342751 | 0.69 | TGFBR1 (0.45) | MAPK14TGFBR1 | |
| SCHEMBL4026671 | 0.68 | MAPK11 (0.68) | MAPK13MAPK9MAPK12MAPK11MAPK14 | |
| SCHEMBL4340200 | 0.67 | TGFBR1 (0.48) | MAPK14TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1786802-A1 | PYRIMIDINYLIMIDAZOLES AS TGF-BETA INHIBITORS | Biogen Idec MA, Inc. (US) | 2007-05-23 | — | — | EP | claimed |
| WO-2006026306-A1 | PYRIMIDINYLIMIDAZOLES AS TGF-BETA INHIBITORS | BIOGEN IDEC MA INC. (US) | 2006-03-09 | — | — | WO | claimed |
| EP-1786802-A1 | PYRIMIDINYLIMIDAZOLES AS TGF-BETA INHIBITORS | Biogen Idec MA, Inc. (US) | 2007-05-23 | — | — | EP | disclosed |
| WO-2006026306-A1 | PYRIMIDINYLIMIDAZOLES AS TGF-BETA INHIBITORS | BIOGEN IDEC MA INC. (US) | 2006-03-09 | — | — | WO | disclosed |