Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 12/20 | 0.56 |
| ▸ | PTGIR | P43119 | 1/20 | 0.49 |
| ▸ | TOP2A | P11388 | 2/20 | 0.47 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.47 |
| ▸ | HTR1D | P28221 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8538139 | 0.85 | NISCH (0.52) | NISCH | |
| SCHEMBL5312093 | 0.76 | NISCH (0.60) | NISCHPTGIRTOP2ATOP2BHTR1D | |
| SCHEMBL3362680 | 0.74 | NISCH (0.57) | NISCHPTGIRHTR1DADRA1AMAOB | |
| SCHEMBL9575256 | 0.73 | NISCH (1.00) | NISCHPTGIRHTR1DADRA1AKDM4E | |
| SCHEMBL5476725 | 0.72 | NISCH (0.79) | NISCHTOP2ATOP2BHTR1DADRA1A | |
| SCHEMBL8196592 | 0.71 | NISCH (0.62) | NISCHPTGIRHTR1DADRA1AMAOB | |
| SCHEMBL549234 | 0.70 | TOP2A (0.57) | NISCHPTGIRTOP2ATOP2BHTR1D | |
| Hydrochloric Acid SCHEMBL7736347 | 0.69 | NISCH (0.53) | NISCHPTGIRKDM4EMAOB | |
| SCHEMBL3360145 | 0.69 | NISCH (0.50) | NISCHPTGIRHTR1DADRA1AMAOB | |
| SCHEMBL14089880 | 0.68 | NISCH (0.79) | NISCHPTGIRTOP2ATOP2BKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007041677-A9 | SOFT TISSUE IMPLANTS AND DRUG COMBINATION COMPOSITIONS, AND USE THEREOF | COMBINATORX INC (US) | 2007-05-31 | — | — | WO | disclosed |
| WO-2007041677-A2 | SOFT TISSUE IMPLANTS AND DRUG COMBINATION COMPOSITIONS, AND USE THEREOF | COMBINATORX, INCORPORATED (US) | 2007-04-12 | — | — | WO | disclosed |