⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL567937 | 0.75 | — | — | |
| SCHEMBL574968 | 0.72 | — | — | |
| Ethylenediamine SCHEMBL28924405 | 0.63 | NFKB1 (0.50) | — | |
| SCHEMBL64333 | 0.63 | — | — | |
| Ethylenediamine SCHEMBL37647 | 0.63 | — | — | |
| Ethylenediamine SCHEMBL30253568 | 0.63 | — | — | |
| Ethylenediamine SCHEMBL7085968 | 0.63 | NFKB1 (0.50) | — | |
| Ethylenediamine SCHEMBL3083 | 0.63 | — | — | |
| Propylamine SCHEMBL23706286 | 0.59 | — | — | |
| Propylamine SCHEMBL31540164 | 0.59 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 582 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3342767-B1 | PYRAZOLYL SUBSTITUTED CARBONIC ACID DERIVATIVES AS MODULATORS OF THE PROSTACYCLIN (PGI2) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARM INC (US) | 2021-04-14 | — | — | EP | claimed |
| US-10689372-B2 | Pyrazolyl substituted carbonic acid derivatives as modulators of the prostacyclin (PGI2) receptor useful for the treatment of disorders related thereto | ARENA PHARMACEUTICALS, INC. (US) | 2020-06-23 | — | — | US | claimed |
| US-20190270731-A1 | PYRAZOLYL SUBSTITUTED CARBONIC ACID DERIVATIVES AS MODULATORS OF THE PROSTACYCLIN (PGI2) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. | 2019-09-05 | — | — | US | claimed |
| EP-3342767-A1 | PYRAZOLYL SUBSTITUTED CARBONIC ACID DERIVATIVES AS MODULATORS OF THE PROSTACYCLIN (PGI2) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2018-07-04 | — | — | EP | claimed |
| EP-2413909-B1 | MULTIAMINO ACID-BASED POLY (ESTER AMIDE)S | UNIV CORNELL (US) | 2016-11-30 | — | — | EP | claimed |
| US-9487553-B2 | Boranophosphate analogues of cyclic nucleotides | BIOLOG LIFE SCIENCE INSTITUTE FORSCHUNGSLABOR UND BIOCHEMICA-VERTRIEB GMBH (DE) | 2016-11-08 | — | — | US | claimed |
| EP-2691403-B1 | NEW BORANOPHOSPHATE ANALOGUES OF CYCLIC NUCLEOTIDES | BIOLOG LIFE SCIENCE INST FORSCHUNGSLABOR UND BIOCHEMICA VERTRIEB GMBH (DE) | 2016-05-18 | — | — | EP | claimed |
| EP-1511757-B1 | NEW COMPOUNDS FOR MODULATING THE ACTIVITY OF EXCHANGE PROTEINS DIRECTLY ACTIVATED BY CAMP (EPACS) | UNIV MEDISCH CENTRUM UTRECHT (NL) | 2015-11-04 | — | — | EP | claimed |
| US-20150191455-A1 | PYRAZOLYL SUBSTITUTED CARBONIC ACID DERIVATIVES AS MODULATORS OF THE PROSTACYCLIN (PGI2) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. | 2015-07-09 | — | — | US | claimed |
| US-9012478-B2 | Pyrazolyl substituted carbonic acid derivatives as modulators of the prostacyclin (PGI2) receptor useful for the treatment of disorders related thereto | ARENA PHARMACEUTICALS, INC. (US) | 2015-04-21 | — | — | US | claimed |
| US-4341706-A | Process for the preparation of carbapenem antibiotics | MERCK & CO., INC. (US) | 1982-07-27 | — | — | US | claimed |
| EP-0055562-A2 | Cephalosporin derivatives | ICI PHARMA (FR) | 1982-07-07 | — | — | EP | claimed |
| EP-0055099-A1 | Penicillin derivatives | ICI PHARMA (FR) | 1982-06-30 | — | — | EP | claimed |
| US-4312871-A | 6-, 1- And 2-substituted-1-carbadethiapen-2-em-3-carboxylic acids | MERCK & CO., INC. (US) | 1982-01-26 | — | — | US | claimed |
| EP-0041768-A2 | Beta-lactam compounds, their preparation and use | BEECHAM GROUP PLC (GB) | 1981-12-16 | — | — | EP | claimed |
| EP-0030032-A2 | 6-, 1- and 2-substituted-1-carbadethiapen-2-em-3-carboxylic acids, processes for preparing the same, pharmaceutical compositions containing the same, and intermediates | MERCK & CO. INC. (US) | 1981-06-10 | — | — | EP | claimed |
| US-4269873-A | PENICILLIN DERIVATIVES | MERCK & CO., INC. (US) | 1981-05-26 | — | — | US | claimed |
| EP-0024832-A1 | Beta-lactam antibiotics, their preparation, pharmaceutical compositions containing them and their preparation | BEECHAM GROUP PLC (GB) | 1981-03-11 | — | — | EP | claimed |
| EP-0017992-A1 | 2-Substituted-6-substituted-1-carbadethiapen-2-em-3-carboxylic acids, processes for preparing them, antibiotic pharmaceutical compositions containing same and process for preparing intermediates | MERCK & CO. INC. (US) | 1980-10-29 | — | — | EP | claimed |
| US-4203902-A | Process for preparing 6- and 2-substituted-1-carbadethiapen-2-em-3-carboxylic acids | MERCK & CO., INC. (US) | 1980-05-20 | — | — | US | claimed |