Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 8/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.49 |
| ▸ | NQO2 | P16083 | 1/20 | 0.47 |
| ▸ | FBP1 | P09467 | 1/20 | 0.46 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5311484 | 1.00 | NFE2L2 (0.55) | NFE2L2PTGS1PTGS2NQO2FBP1 | |
| SCHEMBL5311487 | 1.00 | NFE2L2 (0.55) | NFE2L2PTGS1PTGS2NQO2FBP1 | |
| SCHEMBL1618939 | 0.80 | CYP1A2 (0.60) | MAOB | |
| SCHEMBL3452259 | 0.80 | CYP1A2 (0.60) | MAOB | |
| SCHEMBL2910722 | 0.80 | CYP1A2 (0.60) | MAOB | |
| SCHEMBL8060342 | 0.80 | CYP1A2 (0.60) | MAOB | |
| SCHEMBL3452258 | 0.80 | CYP1A2 (0.60) | MAOB | |
| SCHEMBL11337304 | 0.80 | CYP1A2 (0.60) | MAOB | |
| SCHEMBL8668203 | 0.80 | CYP1A2 (0.60) | MAOB | |
| SCHEMBL11326240 | 0.80 | NFE2L2 (0.50) | NFE2L2PTGS1PTGS2NQO2FBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007044796-A2 | PYRIDAZINONE COMPOUNDS AS CALCILYTICS | NPS PHARMACEUTICALS, INC. (US) | 2007-04-19 | — | — | WO | disclosed |
| WO-2007044796-A2 | PYRIDAZINONE COMPOUNDS AS CALCILYTICS | NPS PHARMACEUTICALS, INC. (US) | 2007-04-19 | — | — | WO | disclosed |