Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.61 |
| ▸ | GAA | P10253 | 9/20 | 0.61 |
| ▸ | HPGD | P15428 | 7/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.61 |
| ▸ | CASP1 | P29466 | 4/20 | 0.61 |
| ▸ | CASP7 | P55210 | 4/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | GLA | P06280 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5481006 | 0.92 | KDM4E (0.72) | ALDH1A1KDM4EGAAHPGDHSD17B10 | |
| SCHEMBL5332854 | 0.91 | KDM4E (0.62) | ALDH1A1KDM4EGAAHPGDHSD17B10 | |
| SCHEMBL5332974 | 0.89 | KDM4E (0.72) | ALDH1A1KDM4EGAAHPGDHSD17B10 | |
| SCHEMBL5478346 | 0.89 | KDM4E (0.72) | ALDH1A1KDM4EGAAHPGDHSD17B10 | |
| SCHEMBL5332893 | 0.88 | ALDH1A1 (0.58) | ALDH1A1KDM4EGAAHPGDHSD17B10 | |
| SCHEMBL3325381 | 0.86 | KDM4E (0.52) | ALDH1A1KDM4EGAAHPGDHSD17B10 | |
| SCHEMBL5311773 | 0.85 | PDE1C (0.52) | ALDH1A1KDM4EGAAHPGDHSD17B10 | |
| SCHEMBL5331931 | 0.85 | KDM4E (0.72) | ALDH1A1KDM4EGAAHPGDHSD17B10 | |
| SCHEMBL3320706 | 0.85 | POLB (0.54) | ALDH1A1KDM4EGAAHPGDHSD17B10 | |
| SCHEMBL5331606 | 0.85 | KDM4E (0.68) | ALDH1A1KDM4EGAAHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070112015-A1 | Substituted dihydropyridines and methods of use | CHEMOCENTRYX, INC. (US) | 2007-05-17 | — | — | US | disclosed |
| WO-2007051062-A2 | SUBSTITUTED DIHYDROPYRIDINES AND METHODS OF USE | CHEMOCENTRYX, INC. (US) | 2007-05-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070112015-A1 | Substituted dihydropyridines and methods of use | C3AR1, C5AR1, C5AR2 | ALDH1A1 1488/4885KDM4E 4033/4885GAA 3421/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.