Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNE1 | P15382 | 1/20 | 0.49 |
| ▸ | CCR1 | P32246 | 1/20 | 0.49 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | CALCA | P06881 | 1/20 | 0.40 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6086875 | 0.89 | KCNE1 (0.49) | KCNE1CCR1KCNQ1L3MBTL1ALDH1A1 | |
| SCHEMBL5309519 | 0.89 | MAPK8 (0.42) | KCNE1CCR1KCNQ1L3MBTL1ALDH1A1 | |
| SCHEMBL5253935 | 0.89 | KCNE1 (0.47) | KCNE1CCR1KCNQ1L3MBTL1ALDH1A1 | |
| SCHEMBL6087562 | 0.88 | KCNH2 (0.50) | KCNE1CCR1KCNQ1L3MBTL1ALDH1A1 | |
| SCHEMBL6087015 | 0.88 | KCNE1 (0.46) | KCNE1CCR1KCNQ1L3MBTL1ALDH1A1 | |
| SCHEMBL6093745 | 0.88 | KCNE1 (0.52) | KCNE1CCR1KCNQ1ALDH1A1KCNH2 | |
| SCHEMBL6094550 | 0.86 | KCNH2 (0.54) | KCNE1CCR1KCNQ1L3MBTL1ALDH1A1 | |
| SCHEMBL6094737 | 0.86 | CYP2C9 (0.56) | KCNE1CCR1KCNQ1L3MBTL1ALDH1A1 | |
| SCHEMBL12776746 | 0.86 | CYP2C9 (0.55) | KCNE1CCR1KCNQ1L3MBTL1ALDH1A1 | |
| SCHEMBL5254454 | 0.86 | KCNE1 (0.45) | KCNE1CCR1KCNQ1L3MBTL1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756069-A4 | HIV INTEGRASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2007-11-28 | — | — | EP | claimed |
| EP-1756069-A2 | HIV INTEGRASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2007-02-28 | — | — | EP | claimed |
| US-7115601-B2 | HIV integrase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-10-03 | — | — | US | claimed |
| WO-2005115398-A2 | HIV INTEGRASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-12-08 | — | — | WO | claimed |
| US-20050261322-A1 | HIV integrase inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2005-11-24 | — | — | US | claimed |
| EP-1833792-A1 | SUBSTITUTED PIPERIDINE COMPOUNDS FOR USE AS CCR5 MODULATORS | AstraZeneca AB (SE) | 2007-09-19 | — | — | EP | disclosed |
| US-7115601-B2 | HIV integrase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-10-03 | — | — | US | disclosed |
| WO-2006067385-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2006-06-29 | — | — | WO | disclosed |
| US-20050261322-A1 | HIV integrase inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2005-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050261322-A1 | HIV integrase inhibitors | TYMP, PAICS, TYMS | KCNE1 3346/4885CCR1 1685/4885KCNQ1 4324/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.