SCHEMBL5312468

SCHEMBL5312468

Cc1nc(NC2CCN(Cc3ccc4c(c3)OCO4)CC2)c2cc(Cl)ccc2n1

nearest known ligand 0.69

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MCHR1 Q99705 20/20 0.69
KCNH2 Q12809 7/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5308436 0.87 MCHR1 (0.66) MCHR1KCNH2
SCHEMBL14543113 0.84 MCHR1 (0.52) MCHR1KCNH2
SCHEMBL5309356 0.83 MCHR1 (0.61) MCHR1KCNH2
SCHEMBL5312221 0.78 MCHR1 (0.60) MCHR1KCNH2
SCHEMBL6208310 0.76 MCHR1 (1.00) MCHR1KCNH2
SCHEMBL15280240 0.75 MCHR1 (0.58) MCHR1KCNH2
SCHEMBL6207395 0.74 MCHR1 (0.73) MCHR1KCNH2
SCHEMBL6309337 0.74 MCHR1 (0.73) MCHR1KCNH2
SCHEMBL2669488 0.73 MCHR1 (1.00) MCHR1KCNH2
SCHEMBL6208117 0.73 MCHR1 (1.00) MCHR1KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007042669-A2 DERIVATIVES OF 4-AMINO-QUINAZOLINE, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS SANOFIS-AVENTIS (FR) 2007-04-19 WO disclosed
WO-2007042669-A2 DERIVATIVES OF 4-AMINO-QUINAZOLINE, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS SANOFIS-AVENTIS (FR) 2007-04-19 WO disclosed