SCHEMBL5312221

SCHEMBL5312221

Cc1cc(Cl)cc2c(NC3CCN(Cc4ccc5c(c4)OCO5)CC3)ncnc12

nearest known ligand 0.60

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MCHR1 Q99705 20/20 0.60
KCNH2 Q12809 6/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14542862 0.84 CNR1 (0.51) MCHR1
SCHEMBL1605047 0.80 HTR2B (0.66) MCHR1KCNH2
SCHEMBL5312468 0.78 MCHR1 (0.69) MCHR1KCNH2
SCHEMBL1653600 0.73 MEN1 (0.70) MCHR1KCNH2
SCHEMBL5308436 0.72 MCHR1 (0.66) MCHR1KCNH2
SCHEMBL5334052 0.72 MCHR1 (0.56) MCHR1KCNH2
SCHEMBL14542257 0.71 MCHR1 (0.72) MCHR1KCNH2
SCHEMBL4125253 0.71 SIGMAR1 (0.62) MCHR1
SCHEMBL2669488 0.71 MCHR1 (1.00) MCHR1KCNH2
SCHEMBL5309356 0.69 MCHR1 (0.61) MCHR1KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007042669-A2 DERIVATIVES OF 4-AMINO-QUINAZOLINE, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS SANOFIS-AVENTIS (FR) 2007-04-19 WO disclosed