Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 14/20 | 0.49 |
| ▸ | PDGFRA | P16234 | 9/20 | 0.49 |
| ▸ | FLT1 | P17948 | 5/20 | 0.49 |
| ▸ | FLT4 | P35916 | 5/20 | 0.49 |
| ▸ | RET | P07949 | 5/20 | 0.49 |
| ▸ | KIT | P10721 | 5/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.49 |
| ▸ | FGFR4 | P22455 | 5/20 | 0.49 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.49 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.49 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.49 |
| ▸ | STK10 | O94804 | 2/20 | 0.49 |
| ▸ | ABL1 | P00519 | 2/20 | 0.49 |
| ▸ | BCR | P11274 | 2/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.49 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.49 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.49 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1893766 | 1.00 | KDR (0.49) | KDRPDGFRAFLT1FLT4RET | |
| SCHEMBL1893767 | 1.00 | KDR (0.49) | KDRPDGFRAFLT1FLT4RET | |
| SCHEMBL1893029 | 0.95 | KDR (0.48) | KDRPDGFRAFLT1FLT4RET | |
| SCHEMBL1248445 | 0.95 | KDR (0.48) | KDRPDGFRAFLT1FLT4RET | |
| SCHEMBL1893032 | 0.95 | KDR (0.48) | KDRPDGFRAFLT1FLT4RET | |
| SCHEMBL1248449 | 0.95 | KDR (0.48) | KDRPDGFRAFLT1FLT4RET | |
| SCHEMBL12673816 | 0.92 | KDR (0.47) | KDRPDGFRAFLT1FLT4RET | |
| SCHEMBL1250646 | 0.90 | KDR (0.49) | KDRPDGFRAFLT1FLT4RET | |
| SCHEMBL1250643 | 0.90 | KDR (0.49) | KDRPDGFRAFLT1FLT4RET | |
| SCHEMBL14693181 | 0.90 | KDR (0.45) | KDRPDGFRAFLT1FLT4RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1415987-B1 | NITROGENOUS AROMATIC RING COMPOUNDS AS ANTI CANCER AGENTS | EISAI R&D MAN CO LTD (JP) | 2007-02-28 | — | — | EP | disclosed |