Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 18/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 8/20 | 0.45 |
| ▸ | MET | P08581 | 8/20 | 0.45 |
| ▸ | AURKA | O14965 | 7/20 | 0.45 |
| ▸ | LCK | P06239 | 7/20 | 0.45 |
| ▸ | TEK | Q02763 | 7/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 9/20 | 0.39 |
| ▸ | KIT | P10721 | 4/20 | 0.39 |
| ▸ | AXL | P30530 | 3/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.39 |
| ▸ | FLT1 | P17948 | 4/20 | 0.38 |
| ▸ | RIPK2 | O43353 | 3/20 | 0.38 |
| ▸ | STK10 | O94804 | 3/20 | 0.38 |
| ▸ | ABL1 | P00519 | 3/20 | 0.38 |
| ▸ | RET | P07949 | 3/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.38 |
| ▸ | FLT4 | P35916 | 3/20 | 0.38 |
| ▸ | DDR1 | Q08345 | 3/20 | 0.38 |
| ▸ | PTK6 | Q13882 | 3/20 | 0.38 |
| ▸ | DDR2 | Q16832 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14693175 | 0.96 | KDR (0.43) | KDRAURKBMETAURKALCK | |
| SCHEMBL14693166 | 0.96 | KDR (0.40) | KDRAURKBMETAURKALCK | |
| SCHEMBL14693173 | 0.90 | KDR (0.41) | KDRAURKBMETAURKALCK | |
| SCHEMBL12673816 | 0.90 | KDR (0.47) | KDRAURKBMETAURKALCK | |
| SCHEMBL1893767 | 0.90 | KDR (0.49) | KDRAURKBMETAURKALCK | |
| SCHEMBL1893766 | 0.90 | KDR (0.49) | KDRAURKBMETAURKALCK | |
| SCHEMBL5312671 | 0.90 | KDR (0.49) | KDRAURKBMETAURKALCK | |
| SCHEMBL14693152 | 0.89 | MET (0.39) | KDRAURKBMETAURKALCK | |
| SCHEMBL14693176 | 0.86 | FGFR2 (0.47) | KDRAURKBMETAURKALCK | |
| SCHEMBL14437826 | 0.86 | KDR (0.57) | KDRAURKBMETAURKALCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8372981-B2 | Nitrogen-containing aromatic derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2013-02-12 | — | — | US | disclosed |