Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | BPTF | Q12830 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2186918 | 1.00 | ATM (0.48) | ATMGAAL3MBTL1MEN1KMT2A | |
| SCHEMBL5315426 | 1.00 | ATM (0.48) | ATMGAAL3MBTL1MEN1KMT2A | |
| SCHEMBL2184936 | 0.98 | ATM (0.50) | ATMGAAL3MBTL1MEN1KMT2A | |
| SCHEMBL31011078 | 0.88 | — | — | |
| Pyridine SCHEMBL28153398 | 0.84 | HTT (0.42) | L3MBTL1MEN1KMT2ATDP1ALDH1A1 | |
| SCHEMBL28191935 | 0.81 | CA2 (0.46) | ATMMEN1KMT2ADPP4LMNA | |
| Piperazine SCHEMBL28191934 | 0.79 | CA2 (0.44) | ATMMEN1KMT2ADPP4LMNA | |
| SCHEMBL27396631 | 0.79 | ATM (0.50) | ATMGAAL3MBTL1MEN1KMT2A | |
| SCHEMBL6886932 | 0.78 | CYP1A2 (0.46) | KMT2ATDP1SMN1; SMN2HTT | |
| SCHEMBL10337221 | 0.78 | ATM (0.56) | ATMGAAL3MBTL1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1592426-B1 | 2-CYANOPYRROLOPYRIMIDINES AND PHARMACEUTICAL USES THEREOF | NOVARTIS AG (CH) | 2007-12-19 | — | — | EP | claimed |