Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 10/20 | 0.46 |
| ▸ | CDK2 | P24941 | 7/20 | 0.46 |
| ▸ | CDK1 | P06493 | 4/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.46 |
| ▸ | CCND1 | P24385 | 3/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.46 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 7/20 | 0.45 |
| ▸ | MAPK9 | P45984 | 6/20 | 0.45 |
| ▸ | JUN | P05412 | 4/20 | 0.45 |
| ▸ | CCND3 | P30281 | 4/20 | 0.43 |
| ▸ | CDK6 | Q00534 | 4/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.43 |
| ▸ | GSK3B | P49841 | 5/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.42 |
| ▸ | IKBKB | O14920 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5315625 | 0.87 | CDK4 (0.46) | CDK4CDK2CDK1CCNA2CCND1 | |
| SCHEMBL8233238 | 0.84 | MAPK8 (0.63) | CDK4CDK2CDK1CCNA2CCND1 | |
| SCHEMBL8236672 | 0.84 | CDK2 (0.55) | CDK4CDK2CDK1CCNA2CCND1 | |
| SCHEMBL5313196 | 0.82 | ADORA2A (0.46) | CDK4CDK2CDK1CCNA2CCND1 | |
| SCHEMBL8233232 | 0.82 | IKBKB (0.48) | CDK4CDK2CDK1CCNA2CCND1 | |
| SCHEMBL8233720 | 0.81 | CDK2 (0.47) | CDK4CDK2CDK1CCNA2CCND1 | |
| SCHEMBL8235871 | 0.79 | CDK4 (0.58) | CDK4CDK2CDK1CCNA2CCND1 | |
| SCHEMBL8227898 | 0.79 | IKBKB (0.60) | CDK4CDK2CDK1CCNA2CCND1 | |
| SCHEMBL8229248 | 0.79 | CDK4 (0.50) | CDK4CDK2CDK1CCNA2CCND1 | |
| SCHEMBL8233031 | 0.78 | PIK3C3 (0.54) | CDK4CDK2CDK1CCNA2CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007129195-A2 | 4-PYRIMIDINE-5-AMINO-PYRAZOLE COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2007-11-15 | — | — | WO | disclosed |