Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 5/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | IDH1 | O75874 | 1/20 | 0.43 |
| ▸ | IDH2 | P48735 | 1/20 | 0.43 |
| ▸ | CDK4 | P11802 | 5/20 | 0.43 |
| ▸ | CDK1 | P06493 | 2/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.43 |
| ▸ | CCND3 | P30281 | 1/20 | 0.43 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.43 |
| ▸ | JUN | P05412 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8234082 | 0.91 | MAPK1 (0.40) | ADORA2ACDK2CCNA2MAPK1CDK4 | |
| SCHEMBL5315625 | 0.85 | CDK4 (0.46) | CDK2CCNA2CDK4CDK1CCNE1 | |
| SCHEMBL5330022 | 0.85 | MAPK8 (0.54) | ADORA2ACDK2CCNA2CDK4CDK1 | |
| SCHEMBL8233720 | 0.83 | CDK2 (0.47) | CDK2CCNA2CDK4CDK1CCNE1 | |
| SCHEMBL8233238 | 0.83 | MAPK8 (0.63) | CDK2CCNA2CDK4CDK1CCNE1 | |
| SCHEMBL5312845 | 0.82 | CDK4 (0.46) | CDK2CCNA2CDK4CDK1CCNE1 | |
| SCHEMBL14190850 | 0.81 | ADORA2A (0.56) | ADORA2ACDK2CCNA2ALDH1A1MAPK1 | |
| SCHEMBL8236159 | 0.81 | BCDIN3D (0.44) | CDK2CCNA2SYKCCNA1CCNT1 | |
| SCHEMBL8235871 | 0.79 | CDK4 (0.58) | CDK2CCNA2CDK4CDK1CCNE1 | |
| SCHEMBL8227898 | 0.79 | IKBKB (0.60) | CDK2CCNA2CDK4CDK1CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007129195-A2 | 4-PYRIMIDINE-5-AMINO-PYRAZOLE COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2007-11-15 | — | — | WO | disclosed |
| WO-2007129195-A2 | 4-PYRIMIDINE-5-AMINO-PYRAZOLE COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2007-11-15 | — | — | WO | disclosed |