Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 17/20 | 0.53 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5311483 | 0.94 | CASR (0.48) | CASRNR1I2 | |
| SCHEMBL5308152 | 0.91 | CASR (0.58) | CASRNR1I2 | |
| SCHEMBL5310117 | 0.91 | CASR (0.45) | CASRNR1I2 | |
| SCHEMBL5309367 | 0.90 | CASR (0.46) | CASRNR1I2 | |
| SCHEMBL5309858 | 0.89 | CASR (0.45) | CASRNR1I2 | |
| SCHEMBL5310559 | 0.85 | CASR (0.57) | CASRNR1I2 | |
| SCHEMBL5308833 | 0.85 | CASR (0.43) | CASRUSP2MAPT | |
| SCHEMBL5310573 | 0.85 | CASR (0.54) | CASRNR1I2 | |
| SCHEMBL5311949 | 0.82 | CASR (0.47) | CASRNR1I2USP2 | |
| SCHEMBL5308868 | 0.82 | GAA (0.42) | CASRTP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007044796-A2 | PYRIDAZINONE COMPOUNDS AS CALCILYTICS | NPS PHARMACEUTICALS, INC. (US) | 2007-04-19 | — | — | WO | claimed |
| WO-2007044796-A2 | PYRIDAZINONE COMPOUNDS AS CALCILYTICS | NPS PHARMACEUTICALS, INC. (US) | 2007-04-19 | — | — | WO | disclosed |
| WO-2007044796-A2 | PYRIDAZINONE COMPOUNDS AS CALCILYTICS | NPS PHARMACEUTICALS, INC. (US) | 2007-04-19 | — | — | WO | disclosed |