Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 17/20 | 0.57 |
| ▸ | NR1I2 | O75469 | 6/20 | 0.57 |
| ▸ | GNRHR | P30968 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5311242 | 0.91 | CASR (0.49) | CASRNR1I2GNRHR | |
| SCHEMBL5313138 | 0.85 | CASR (0.53) | CASRNR1I2 | |
| SCHEMBL5310430 | 0.85 | CASR (0.43) | CASRNR1I2GNRHR | |
| SCHEMBL5311483 | 0.84 | CASR (0.48) | CASRNR1I2 | |
| SCHEMBL5308152 | 0.84 | CASR (0.58) | CASRNR1I2 | |
| SCHEMBL5309367 | 0.83 | CASR (0.46) | CASRNR1I2 | |
| SCHEMBL5310573 | 0.78 | CASR (0.54) | CASRNR1I2 | |
| SCHEMBL5310117 | 0.78 | CASR (0.45) | CASRNR1I2 | |
| SCHEMBL5316086 | 0.77 | CASR (0.41) | CASRNR1I2GNRHR | |
| SCHEMBL5309858 | 0.76 | CASR (0.45) | CASRNR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007044796-A2 | PYRIDAZINONE COMPOUNDS AS CALCILYTICS | NPS PHARMACEUTICALS, INC. (US) | 2007-04-19 | — | — | WO | claimed |
| WO-2007044796-A2 | PYRIDAZINONE COMPOUNDS AS CALCILYTICS | NPS PHARMACEUTICALS, INC. (US) | 2007-04-19 | — | — | WO | disclosed |
| WO-2007044796-A2 | PYRIDAZINONE COMPOUNDS AS CALCILYTICS | NPS PHARMACEUTICALS, INC. (US) | 2007-04-19 | — | — | WO | disclosed |