SCHEMBL5313276

SCHEMBL5313276

O=Cc1cccc(-c2nn(Cc3ccccc3)c3ccccc23)n1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDE5A O76074 4/20 0.48
CYP2D6 P10635 4/20 0.48
CYP1A2 P05177 3/20 0.48
CYP3A4 P08684 2/20 0.48
SCN8A Q9UQD0 1/20 0.48
ALDH1A1 P00352 2/20 0.46
HSD17B10 Q99714 2/20 0.46
KDM4E B2RXH2 1/20 0.46
NPC1 O15118 1/20 0.46
GMNN O75496 1/20 0.46
LMNA P02545 1/20 0.46
TP53 P04637 1/20 0.46
MAPT P10636 1/20 0.46
CYP2C9 P11712 1/20 0.46
HPGD P15428 1/20 0.46
ALOX15 P16050 1/20 0.46
NFKB1 P19838 1/20 0.46
MAPK1 P28482 1/20 0.46
CYP2C19 P33261 1/20 0.46
RAB9A P51151 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5314636 0.79 PDE5A (0.56) PDE5ACYP2D6CYP1A2CYP3A4SCN8A
SCHEMBL1225203 0.74 CNR1 (0.54) PDE5ACYP2D6CYP1A2CYP3A4SCN8A
SCHEMBL3069801 0.73 PDE5A (0.49) PDE5ACYP2D6CYP1A2CYP3A4SCN8A
SCHEMBL3621787 0.73 ALDH1A1 (0.67) PDE5ACYP2D6CYP1A2CYP3A4SCN8A
SCHEMBL5311492 0.73 CYP2D6 (0.47) PDE5ACYP2D6CYP1A2CYP3A4SCN8A
SCHEMBL3072072 0.72 PDE5A (0.67) PDE5ACYP2D6CYP1A2CYP3A4SCN8A
SCHEMBL5560789 0.72 PDE5A (0.57) PDE5ACYP2D6CYP1A2CYP3A4SCN8A
SCHEMBL13865211 0.70 CYP2D6 (0.57) PDE5ACYP2D6CYP1A2CYP3A4SCN8A
SCHEMBL17696321 0.70 CNR1 (0.59) PDE5ACYP2D6CYP1A2CYP3A4SCN8A
SCHEMBL6011543 0.70 PDE5A (0.57) PDE5ACYP2D6CYP1A2CYP3A4SCN8A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007065010-A2 ANTI-ANGIOGENESIS COMPOUNDS HIF BIO, INC. (US) 2007-06-07 WO disclosed
EP-1686127-A1 New heterocyclylmethyl-substituted pyrazole derivatives and their use for treating cardiovascular diseases Bayer HealthCare AG (DE) 2006-08-02 EP disclosed
US-6462068-B1 CARDIOVASCULAR DISEASES BAYER AKTIENGESELLSCHAFT (DE) 2002-10-08 US disclosed
US-6414009-B1 CARDIOVASCULAR DISORDERS; ANTICOAGULANTS BAYER AKTIENGESELLSCHAFT (DE) 2002-07-02 US disclosed
US-6410740-B1 CYCLIZATION OF THE CORRESPONDING AMIDE BAYER AKTIENGESELLSCHAFT (DE) 2002-06-25 US disclosed
US-6387940-B1 CARDIOVASCULAR DISORDERS BAYER AKTIENGESELLSCHAFT (DE) 2002-05-14 US disclosed
US-6166027-A Heterocyclylmethyl-substituted pyrazole derivatives and their use for treating cardiovascular diseases BAYER AKTIENGESELLSCHAFT (DE) 2000-12-26 US disclosed
EP-0934311-A2 NEW HETEROCYCLYLMETHYL-SUBSTITUTED PYRAZOL DERIVATES BAYER AG (DE) 1999-08-11 EP disclosed
WO-1998016507-A2 NEW HETEROCYCLYLMETHYL-SUBSTITUTED PYRAZOL DERIVATES AND THEIR USE FOR TREATING CARDIOVASCULAR DISEASES BAYER AKTIENGESELLSCHAFT (DE) 1998-04-23 WO disclosed