Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 2/20 | 0.43 |
| ▸ | GPR3 | P46089 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 6/20 | 0.37 |
| ▸ | POLB | P06746 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.37 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.37 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.37 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | PTPRC | P08575 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7427769 | 0.71 | GPR3 (0.39) | GPR3ALDH1A1ALOX15MAPTPOLB | |
| SCHEMBL3318555 | 0.70 | GPR3 (0.50) | GPR3ALDH1A1ALOX15MAPTPOLB | |
| SCHEMBL23621007 | 0.68 | GPR3 (0.48) | GPR3ALDH1A1ALOX15MAPTPOLB | |
| SCHEMBL6545120 | 0.67 | GPR3 (0.52) | GPR3ALDH1A1ALOX15MAPTMEN1 | |
| SCHEMBL7322569 | 0.66 | GPR3 (0.36) | GPR3ALDH1A1ALOX15MAPTPOLB | |
| SCHEMBL5341185 | 0.66 | KDM4E (0.38) | GPR3ALDH1A1ALOX15MAPTPOLB | |
| SCHEMBL11793572 | 0.66 | CES1 (0.50) | CES1ALDH1A1ALOX15MAPTPOLB | |
| SCHEMBL30288157 | 0.66 | CES1 (0.50) | CES1ALDH1A1ALOX15MAPTPOLB | |
| SCHEMBL17716757 | 0.64 | HSP90AA1 (0.43) | CES1GPR3ALDH1A1ALOX15MAPT | |
| SCHEMBL16875878 | 0.64 | HSP90AA1 (0.43) | CES1GPR3ALDH1A1ALOX15MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1545544-A2 | COMBINATIONS OF DRUGS FOR THE TREATMENT OF NEOPLASMS | Combinatorx, Incorporated (US) | 2005-06-29 | — | — | EP | claimed |
| WO-2004006842-A2 | COMBINATIONS OF DRUGS FOR THE TREATMENT OF NEOPLASMS | COMBINATORX, INCORPORATED (US) | 2004-01-22 | — | — | WO | claimed |
| CN-103626964-A | Carbazole unit-containing polymer, preparation method of carbazole unit-containing polymer and organic electroluminescent device | ZHOU MINGJIE | 2014-03-12 | — | — | CN | disclosed |
| WO-2007041677-A9 | SOFT TISSUE IMPLANTS AND DRUG COMBINATION COMPOSITIONS, AND USE THEREOF | COMBINATORX INC (US) | 2007-05-31 | — | — | WO | disclosed |
| WO-2007041677-A2 | SOFT TISSUE IMPLANTS AND DRUG COMBINATION COMPOSITIONS, AND USE THEREOF | COMBINATORX, INCORPORATED (US) | 2007-04-12 | — | — | WO | disclosed |