Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 8/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14026855 | 0.87 | REN (0.44) | RENHDAC1HDAC8HDAC6MAPT | |
| SCHEMBL4155087 | 0.76 | JAK2 (0.40) | RENMAPTGPR119CYP3A4KCNH2 | |
| SCHEMBL14026912 | 0.74 | USP30 (0.42) | RENMAPTGPR119JAK2JAK1 | |
| SCHEMBL8265069 | 0.73 | TACR1 (0.41) | RENGPR119CYP3A4JAK2JAK1 | |
| SCHEMBL10183402 | 0.73 | TACR1 (0.44) | RENGPR119CYP3A4KCNH2JAK2 | |
| SCHEMBL8259614 | 0.72 | TACR1 (0.41) | RENHDAC1HDAC8HDAC6CYP3A4 | |
| SCHEMBL8265387 | 0.71 | TACR1 (0.42) | RENGPR119CYP3A4KCNH2JAK2 | |
| SCHEMBL6717349 | 0.70 | HDAC1 (0.43) | HDAC1HDAC8HDAC6MAPTGPR119 | |
| SCHEMBL8265393 | 0.70 | USP30 (0.43) | RENGPR119CYP3A4JAK2JAK1 | |
| SCHEMBL10183689 | 0.69 | TACR1 (0.43) | RENGPR119CYP3A4KCNH2JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007034445-A2 | NOVEL PIPERAZINE DERIVATIVES AS RENIN INHIBITORS FOR CARDIOVASCULAR EVENTS AND RENAL INSUFFICIENCY | ACTELION PHARMACEUTICALS LTD (CH) | 2007-03-29 | — | — | WO | disclosed |