Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 4/20 | 0.55 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.43 |
| ▸ | INSR | P06213 | 7/20 | 0.40 |
| ▸ | IGF1R | P08069 | 5/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | ROS1 | P08922 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.39 |
| ▸ | STK3 | Q13188 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3442499 | 0.80 | SLC2A1 (0.84) | SLC2A1KDRAURKBAURKACDK19 | |
| SCHEMBL5225783 | 0.80 | SLC2A1 (0.51) | SLC2A1KDRAURKBAURKACDK19 | |
| SCHEMBL5229420 | 0.78 | SLC2A1 (0.55) | SLC2A1KDRAURKBAURKACDK19 | |
| SCHEMBL5222829 | 0.78 | SLC2A1 (0.53) | SLC2A1KDRAURKBAURKACDK19 | |
| SCHEMBL5225154 | 0.77 | SLC2A1 (0.46) | SLC2A1KDRAURKBAURKACDK19 | |
| SCHEMBL5223864 | 0.75 | SLC2A1 (0.42) | SLC2A1KDRAURKBAURKACDK19 | |
| SCHEMBL3442101 | 0.73 | SLC2A1 (0.73) | SLC2A1KDRAURKBAURKACDK19 | |
| SCHEMBL3442202 | 0.73 | SLC2A1 (0.69) | SLC2A1KDRAURKBAURKACDK19 | |
| SCHEMBL13105460 | 0.72 | SLC2A1 (0.70) | SLC2A1KDRAURKBAURKACDK19 | |
| SCHEMBL3442009 | 0.71 | SLC2A1 (1.00) | SLC2A1KDRAURKBAURKACDK19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828185-A2 | 2-PYRIMIDINYL PYRAZOLOPYRIDINE ERBB KINASE INHIBITORS | SmithKline Beecham Corporation (US) | 2007-09-05 | — | — | EP | claimed |
| WO-2006068826-A2 | 2-PYRIMIDINYL PYRAZOLOPYRIDINE ERBB KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-06-29 | — | — | WO | claimed |