Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 3/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.35 |
| ▸ | GSK3A | P49840 | 2/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | LTK | P29376 | 1/20 | 0.35 |
| ▸ | GRK5 | P34947 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.35 |
| ▸ | CLK2 | P49760 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL5256029 | 0.86 | ALK (0.39) | ALKGSK3AAURKADAPK3PRKD3 | |
| SCHEMBL5255729 | 0.78 | CHEK1 (0.43) | ALKGSK3AAURKADAPK3PRKD3 | |
| SCHEMBL5255277 | 0.75 | CHEK1 (0.44) | ARALKGSK3AAURKADAPK3 | |
| SCHEMBL3935762 | 0.73 | CHEK1 (0.58) | ALKGSK3AAURKADAPK3PRKD3 | |
| SCHEMBL4518666 | 0.72 | PDGFRB (0.46) | PDGFRBFGFR1FLT1KDRCHEK1 | |
| Hydrochloric Acid SCHEMBL7206364 | 0.71 | CHEK1 (0.46) | PDGFRBFGFR1FLT1KDRCHEK1 | |
| SCHEMBL3942219 | 0.70 | CHEK1 (0.60) | ALKGSK3AAURKADAPK3PRKD3 | |
| SCHEMBL7211306 | 0.67 | CHEK1 (0.54) | PDGFRBFGFR1FLT1KDRCHEK1 | |
| SCHEMBL6511852 | 0.65 | CHEK1 (0.39) | ALKGSK3AAURKADAPK3PRKD3 | |
| SCHEMBL7206414 | 0.62 | KDR (0.46) | FGFR1FLT1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458707-B1 | New Indol-2-one derivatives | ASTRAZENECA AB (SE) | 2007-05-02 | — | — | EP | claimed |