Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.46 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 11/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | FBP1 | P09467 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4518666 | 0.93 | PDGFRB (0.46) | CHEK1PDGFRBMAPK7KDREGFR | |
| Hydrochloric Acid SCHEMBL7206364 | 0.92 | CHEK1 (0.46) | CHEK1PDGFRBMAPK7KDREGFR | |
| SCHEMBL7205793 | 0.85 | KDR (0.48) | KDRFGFR1FLT1FBP1 | |
| Hydrochloric Acid SCHEMBL7209976 | 0.85 | KDR (0.47) | KDREGFR | |
| SCHEMBL4519142 | 0.85 | CHEK1 (0.77) | CHEK1PDGFRBKDREGFR | |
| Hydrochloric Acid SCHEMBL4518036 | 0.85 | PDGFRB (0.53) | CHEK1PDGFRBMAPK7KDREGFR | |
| SCHEMBL7205822 | 0.84 | BRAF (0.46) | MAPK7KDREGFRABCG2FGFR1 | |
| Hydrochloric Acid SCHEMBL4502484 | 0.83 | FBP1 (0.50) | KDREGFRFGFR1FLT1FBP1 | |
| SCHEMBL7206414 | 0.83 | KDR (0.46) | KDRFGFR1FLT1FBP1 | |
| Hydrochloric Acid SCHEMBL7211167 | 0.82 | KDR (0.45) | KDRFGFR1FLT1FBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0912557-B1 | OXINDOLE DERIVATIVES | ASTRAZENECA AB (SE) | 2003-07-09 | — | — | EP | disclosed |
| US-6265411-B1 | ANGIOGENESIS INHIBITOR | ZENECA LIMITED (GB) | 2001-07-24 | — | — | US | disclosed |
| EP-0912557-A1 | OXINDOLE DERIVATIVES | ZENECA LIMITED (GB) | 1999-05-06 | — | — | EP | disclosed |
| WO-1997042187-A1 | OXINDOLE DERIVATIVES | ZENECA LIMITED (GB) | 1997-11-13 | — | — | WO | disclosed |