SCHEMBL5313666

SCHEMBL5313666

O=C([N]Cl)Nc1ccccc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.56
TP53 P04637 1/20 0.56
EPHX1 P07099 1/20 0.56
TSHR P16473 1/20 0.56
EPHX2 P34913 1/20 0.56
CDK9 P50750 1/20 0.56
CLK4 Q9HAZ1 1/20 0.56
NAPRT Q6XQN6 1/20 0.52
HSD17B10 Q99714 1/20 0.52
MAPT P10636 5/20 0.50
ALDH1A1 P00352 3/20 0.50
LMNA P02545 2/20 0.50
GAA P10253 1/20 0.50
ATM Q13315 1/20 0.50
NPSR1 Q6W5P4 2/20 0.48
CYP1A2 P05177 1/20 0.48
POLB P06746 1/20 0.48
CASP3 P42574 1/20 0.48
SENP7 Q9BQF6 1/20 0.48
MEN1 O00255 4/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11650361 0.81 EPHX2 (0.61) SMN1; SMN2TP53EPHX1TSHREPHX2
SCHEMBL10457010 0.81 EPHX2 (0.61) SMN1; SMN2TP53EPHX1TSHREPHX2
Benzene SCHEMBL6243713 0.80 EPHX2 (0.54) SMN1; SMN2TP53EPHX1TSHREPHX2
SCHEMBL1729493 0.80 EPHX2 (0.54) SMN1; SMN2TP53EPHX1TSHREPHX2
SCHEMBL3175598 0.79 SMN1; SMN2 (0.58) SMN1; SMN2TP53EPHX1TSHREPHX2
SCHEMBL8396654 0.77 TP53 (0.56) SMN1; SMN2TP53EPHX1TSHREPHX2
SCHEMBL897272 0.77 HSD17B10 (0.58) SMN1; SMN2TP53EPHX1TSHREPHX2
SCHEMBL5681693 0.77 EPHX2 (0.56) SMN1; SMN2TP53EPHX1TSHREPHX2
SCHEMBL8393640 0.77 SMN1; SMN2 (0.56) SMN1; SMN2TP53EPHX1TSHREPHX2
SCHEMBL9360689 0.77 EPHX2 (0.56) SMN1; SMN2TP53EPHX1TSHREPHX2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007049262-A1 Methods and compositions for the promotion of neuronal growth and the treatment of asociality and affective disorders BERAND LIMITED (IE) 2007-05-03 WO claimed
US-4250319-A RIPENER FOR SUGARCANE W. R. GRACE & CO. (US) 1981-02-10 US claimed
CN-109069516-A Small molecule for mouse satellite cell Proliferation 哈佛学院校长同事会 2018-12-21 CN disclosed
US-5864043-A CARDIOVASCULAR DISORDERS AND ANGIOTENSIN ANTAGONIST KARL THOMAE GMBH (DE) 1999-01-26 US disclosed
US-5541229-A ANGIOITENSIN II ANTAGONIST AS HYPOTENSIVE AGENTS, ANTIISCHEMIC AGENTS AND CARDIOVASCULAR DISORDERS DR. KARL THOMAE GMBH (DE) 1996-07-30 US disclosed
US-4241168-A TWO-EQUIVALENT MAGENTA COUPLER FUJI PHOTO FILM CO., LTD. (JP) 1980-12-23 US disclosed
US-4237217-A IN WHICH COUPLING POSITION IS SUBSTITUTED WITH A SULFONAMIDO GROUP FUJI PHOTO FILM CO., LTD. (JP) 1980-12-02 US disclosed
US-4220470-A TWO-EQUIVALENT COUPLERS FUJI PHOTO FILM CO., LTD. (JP) 1980-09-02 US disclosed
US-4120723-A PYRAZOLONE COUPLER, PHENOLIC COLOR IMAGE STABILIZER FUJI PHOTO FILM CO., LTD. (JP) 1978-10-17 US disclosed
US-4076533-A MAGENTA DYE FUJI PHOTO FILM CO., LTD. (JA) 1978-02-28 US disclosed
US-4040836-A MAGENTA FUJI PHOTO FILM CO., LTD. (JA) 1977-08-09 US disclosed
US-4040835-A Two-equivalent magenta couplers with amido coupling-off groups FUJI PHOTO FILM CO., LTD. (JA) 1977-08-09 US disclosed
US-4040829-A SILVER HALIDE EMULSIONS, SEMI-DIFFUSIBLE COUPLER FUJI PHOTO FILM CO., LTD. (JA) 1977-08-09 US disclosed
US-4032346-A 5-OXO-2-PYRAZOLIN-4-YL-AMINE-CARBODITHIOATE-DITHIOCARBONATE FUJI PHOTO FILM CO., LTD. (JA) 1977-06-28 US disclosed