Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK4 | O96013 | 3/20 | 0.34 |
| ▸ | PLK4 | O00444 | 1/20 | 0.34 |
| ▸ | ABCG2 | Q9UNQ0 | 8/20 | 0.34 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.34 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.34 |
| ▸ | PRKCA | P17252 | 1/20 | 0.34 |
| ▸ | CCR4 | P51679 | 3/20 | 0.33 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4529942 | 0.89 | PAK4 (0.39) | PAK4PLK4PRKCQPRKCDPRKCA | |
| SCHEMBL4531067 | 0.85 | PAK4 (0.37) | PAK4PRKCQPRKCDPRKCACCR4 | |
| SCHEMBL4521530 | 0.84 | CCR4 (0.36) | PAK4PRKCQPRKCDPRKCACCR4 | |
| SCHEMBL4511804 | 0.83 | ALDH1A1 (0.44) | PAK4PLK4ABCG2PRKCQPRKCD | |
| SCHEMBL4521519 | 0.82 | CCR4 (0.36) | PAK4ABCG2PRKCQPRKCDPRKCA | |
| SCHEMBL4513370 | 0.81 | ABCG2 (0.36) | ABCG2PRKCQPRKCDCCR4 | |
| SCHEMBL4528939 | 0.80 | ABCG2 (0.40) | PAK4PLK4ABCG2 | |
| SCHEMBL4515702 | 0.80 | PRKCQ (0.34) | ABCG2PRKCQPRKCDCCR4 | |
| SCHEMBL4533134 | 0.79 | HSD17B10 (0.48) | — | |
| SCHEMBL4521438 | 0.79 | IGF1R (0.40) | PAK4PRKCQPRKCDPAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831216-A2 | HETEROAROMATIC DERIVATIVES USEFUL AS ANTICANCER AGENTS | Pfizer Products Inc. (US) | 2007-09-12 | — | — | EP | claimed |
| WO-2006067614-A2 | HETEROAROMATIC DERIVATIVES USEFUL AS ANTICANCER AGENTS | PFIZER PRODUCTS INC. (US) | 2006-06-29 | — | — | WO | claimed |