Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MELK | Q14680 | 6/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL531593 | 0.88 | TSHR (0.50) | MELKMAPK1RXFP1GAANPSR1 | |
| SCHEMBL15191331 | 0.87 | MELK (0.56) | MELKMAPK1RXFP1GAANPSR1 | |
| SCHEMBL15191333 | 0.87 | MELK (0.56) | MELKMAPK1RXFP1GAANPSR1 | |
| SCHEMBL529607 | 0.85 | MELK (0.46) | MELKMAPK1RXFP1GAANPSR1 | |
| SCHEMBL15197546 | 0.81 | MELK (0.58) | MELKMAPK1RXFP1GAANPSR1 | |
| SCHEMBL15191245 | 0.77 | MELK (0.71) | MELK | |
| SCHEMBL15197582 | 0.77 | MELK (0.71) | MELK | |
| SCHEMBL15191246 | 0.77 | MELK (0.71) | MELK | |
| SCHEMBL15199650 | 0.77 | MELK (0.51) | MELKMAPK1RXFP1GAANPSR1 | |
| SCHEMBL15191468 | 0.76 | MELK (0.57) | MELKMAPK1RXFP1GAANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2597955-A1 | QUINOLINE DERIVATIVES AND MELK INHIBITORS CONTAINING THE SAME | OncoTherapy Science, Inc. (JP) | 2013-06-05 | — | — | EP | disclosed |
| WO-2012016082-A1 | QUINOLINE DERIVATIVES AND MELK INHIBITORS CONTAINING THE SAME | ONCOTHERAPY SCIENCE, INC. (JP) | 2012-02-02 | — | — | WO | disclosed |