Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | MELK | Q14680 | 17/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL529607 | 0.89 | MELK (0.46) | TSHRHTTMELKMAPK1GAA | |
| SCHEMBL531466 | 0.88 | MELK (0.47) | TSHRHTTMELKMAPK1GAA | |
| SCHEMBL15190935 | 0.86 | MELK (0.54) | TSHRHTTMELK | |
| SCHEMBL528868 | 0.86 | MELK (0.54) | TSHRHTTMELK | |
| SCHEMBL529137 | 0.81 | MELK (0.68) | MELK | |
| SCHEMBL15197562 | 0.79 | MELK (0.56) | TSHRHTTMELK | |
| SCHEMBL529083 | 0.78 | MELK (0.67) | MELK | |
| SCHEMBL10282302 | 0.78 | MELK (0.67) | MELK | |
| SCHEMBL18843793 | 0.78 | PDE4B (0.54) | TSHRHTTMELKMAPK1 | |
| SCHEMBL10282359 | 0.77 | MELK (0.72) | MELK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2597955-A1 | QUINOLINE DERIVATIVES AND MELK INHIBITORS CONTAINING THE SAME | OncoTherapy Science, Inc. (JP) | 2013-06-05 | — | — | EP | disclosed |
| WO-2012016082-A1 | QUINOLINE DERIVATIVES AND MELK INHIBITORS CONTAINING THE SAME | ONCOTHERAPY SCIENCE, INC. (JP) | 2012-02-02 | — | — | WO | disclosed |